Focal adhesion kinase (FAK) is a ubiquitous intracellular non-receptor tyrosine kinase,
which is involved in multiple cellular functions, including cell adhesion, migration, invasion …

Recent studies have indicated that homeobox A3 (HOXA3) functions as a carcinogen in
colon cancer and the methylation level of HOXA3 is significantly increased in lung …

Resistance to currently available targeted therapies significantly hampers the survival of
patients with prostate cancer with bone metastasis. Here we demonstrate an important …

EphA10 (erythropoietin‐producing hepatocellular carcinoma receptor A10) is a catalytically
defective receptor protein tyrosine kinase in the ephrin receptor family. Although EphA10 is …

Background and Objectives: Over decades, prostate cancer (PCa) has become one of the
leading causes of cancer mortality in men. Extensive evidence exists that microRNAs …

Pharmacogenomic analysis based on drug transcriptomic signatures is widely used to
identify mechanisms of action and pharmacological indications. Despite accumulating …

Triple-negative breast cancer (TNBC) is a special subtype of breast cancer in which several
common diagnostic biomarkers are lost. Due to the loss of expression of receptors, treatment …

Telomerase is known to contribute to telomere maintenance and to provide cancer cell
immortality. However, numerous reports are showing that the function of the enzyme goes …

Background Recent therapeutic strategies for KRAS-mutated cancers that inhibit the MAPK
pathway have attracted considerable attention. The RAF/MEK clamp avutometinib (VS …

A family of carbonyl-substituted diphenylpyrimidine derivatives (Car-DPPYs) with strong
activity against focal adhesion kinase (FAK), were described in this manuscript. Among …