Integration of mechanical and ECM microenvironment signals in the determination of cancer stem cell states
TA Jokela, MA LaBarge - Current stem cell reports, 2021 - Springer
Abstract Purpose of Review Cancer stem cells (CSCs) are increasingly understood to play a
central role in tumor progression. Growing evidence implicates tumor microenvironments as …
central role in tumor progression. Growing evidence implicates tumor microenvironments as …
[HTML][HTML] Continuous dynamic modeling of regulated cell adhesion: sorting, intercalation, and involution
Cell-cell adhesion is essential for tissue growth and multicellular pattern formation and
crucial for the cellular dynamics during embryogenesis and cancer progression …
crucial for the cellular dynamics during embryogenesis and cancer progression …
[HTML][HTML] WISP-3 inhibition of miR-452 promotes VEGF-A expression in chondrosarcoma cells and induces endothelial progenitor cells angiogenesis
Chondrosarcoma is the second most prevalent general primary tumor of bone following
osteosarcoma. Chondrosarcoma development may be linked to angiogenesis, which is …
osteosarcoma. Chondrosarcoma development may be linked to angiogenesis, which is …
[HTML][HTML] Phase I study of the focal adhesion kinase inhibitor BI 853520 in Japanese and Taiwanese patients with advanced or metastatic solid tumors
Background Focal adhesion kinase (FAK) inhibitors have demonstrated anti-tumor activity
preclinically and are currently being evaluated in humans. A first-in-human study evaluating …
preclinically and are currently being evaluated in humans. A first-in-human study evaluating …
High sensitivity proteomics of prostate cancer tissue microarrays to discriminate between healthy and cancerous tissue
Biopsies, in the form of tissue microarrays (TMAs) were studied to identify anomalies
indicative of prostate cancer at the proteome level. TMAs offer a valuable source of well …
indicative of prostate cancer at the proteome level. TMAs offer a valuable source of well …
DNA hypermethylation of extracellular matrix‐related genes in human periodontal fibroblasts induced by stimulation for a prolonged period with lipopolysaccharide …
Objectives and Background The involvement of DNA methylation in periodontal disease is
not clear. Lipopolysaccharide (LPS) derived from Porphyromonas gingivalis is involved in …
not clear. Lipopolysaccharide (LPS) derived from Porphyromonas gingivalis is involved in …
[HTML][HTML] FAK tyrosine phosphorylation is regulated by AMPK and controls metabolism in human skeletal muscle
DG Lassiter, C Nylén, RJO Sjögren, AV Chibalin… - Diabetologia, 2018 - Springer
Aims/hypothesis Insulin-mediated signals and AMP-activated protein kinase (AMPK)-
mediated signals are activated in response to physiological conditions that represent energy …
mediated signals are activated in response to physiological conditions that represent energy …
Design, synthesis, and biological evaluation of novel covalent inhibitors targeting focal adhesion kinase
T Chen, Y Liu, M Shi, M Tang, W Si, X Yuan… - Bioorganic & Medicinal …, 2021 - Elsevier
Forty-one new focal adhesion kinase (FAK) covalent inhibitors were designed and
synthesized based on FAK inhibitor TAE226. Compound 11w displayed the highest …
synthesized based on FAK inhibitor TAE226. Compound 11w displayed the highest …
Decoding the anticancer activity of VO-clioquinol compound: the mechanism of action and cell death pathways in human osteosarcoma cells
Vanadium compounds were studied in recent years by considering them as a representative
of a new class of non-platinum metal anticancer drugs. However, a few challenges still …
of a new class of non-platinum metal anticancer drugs. However, a few challenges still …
Gambogic acid and its role in chronic diseases
Kokum, a spice derived from the fruit of the Garcinia hanburyi tree, is traditionally used in
Ayurvedic medicines to facilitate digestion and to treat sores, dermatitis, diarrhoea …
Ayurvedic medicines to facilitate digestion and to treat sores, dermatitis, diarrhoea …