Myocardial fibrosis is the heart's common healing response to injury. While initially seeking
to optimize the strength of diseased tissue, fibrosis can become maladaptive, producing stiff …

Giant cell arteritis (GCA) and polymyalgia rheumatica (PMR) are two interrelated
inflammatory diseases affecting patients above 50 years of age. Patients with GCA suffer …

Angiogenesis is a common feature of many physiological processes and pathological
conditions. RGD-containing peptides can strongly bind to integrin αvβ3 expressed on …

As the complications of atherosclerosis such as myocardial infarction and stroke are still one
of the leading causes of mortality worldwide, the development of new diagnostic tools for the …

Background 18 F-NaF positron emission tomography (PET) targets microcalcifications. We
compared in vitro microPET assessed 18 F-NaF uptake between culprit and non-culprit …

Molecular imaging, with major advances in the development of both innovative targeted
contrast agents/particles and radiotracers, as well as various imaging technologies, is a …

Objectives Intraplaque angiogenesis and inflammation are key promoters of atherosclerosis
and are mediated by the alpha-V beta-3 (αvβ3) integrin pathway. We investigated the …

Background Integrin alpha-V-beta-3 (αvβ3) pathway is involved in intraplaque angiogenesis
and inflammation and represents a promising target for molecular imaging in cardiovascular …

Introduction Non-invasive imaging techniques (especially single-photon emission
tomography and positron emission tomography) apply several RGD-based imaging ligands …

Advances in imaging instrumentation and technology have greatly contributed to nuclear
cardiology. Dedicated cardiac SPECT cameras incorporating novel, highly efficient detector …