Alzheimer's disease (AD) is the leading cause of dementia in elderly people. Amyloid beta
(Aβ) deposits and neurofibrillary tangles are the major pathological features in an …

During aging, the cellular milieu of the brain exhibits tell-tale signs of compromised
bioenergetics, impaired adaptive neuroplasticity and resilience, aberrant neuronal network …

Neuritic plaques, a pathological hallmark in Alzheimer's disease (AD) brains, comprise
extracellular aggregates of amyloid-beta (Aβ) peptide and degenerating neurites that …

Frontotemporal dementia is an umbrella clinical term that encompasses a group of
neurodegenerative diseases characterised by progressive deficits in behaviour, executive …

Frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) are fatal
neurodegenerative disorders that are thought to exist on a clinical and pathological …

The behavioural variant of frontotemporal dementia (bvFTD) is a frequent cause of early-
onset dementia. The diagnosis of bvFTD remains challenging because of the limited …

The mechanisms by which mutations in FUS and other RNA binding proteins cause ALS
and FTD remain controversial. We propose a model in which low-complexity (LC) domains …

For several decades scientists have speculated that the key to understanding age-related
neurodegenerative disorders may be found in the unusual biology of the prion diseases …

A hexanucleotide repeat expansion (HRE),(GGGGCC) n, in C9orf72 is the most common
genetic cause of the neurodegenerative diseases amyotrophic lateral sclerosis (ALS) and …

Mitochondria and the endoplasmic reticulum (ER) form tight structural associations and
these facilitate a number of cellular functions. However, the mechanisms by which regions of …