Bile acids in intrahepatic cholestasis of pregnancy
M Majsterek, M Wierzchowska-Opoka, I Makosz… - Diagnostics, 2022 - mdpi.com
Intrahepatic cholestasis of pregnancy (ICP) is the most common, reversible, and closely
related to pregnancy condition characterized by elevated levels of bile acids (BAs) in blood …
related to pregnancy condition characterized by elevated levels of bile acids (BAs) in blood …
Rab7a-mTORC1 signaling-mediated cholesterol trafficking from the lysosome to mitochondria ameliorates hepatic lipotoxicity induced by aflatoxin B1 exposure
JX Lin, CY Xu, XM Wu, L Che, TY Li, SM Mo, DB Guo… - Chemosphere, 2023 - Elsevier
Abstract Aflatoxin B1 (AFB1) is a common contaminant in many foodstuffs and is considered
a public health concern worldwide due to its hepatotoxicity caused by lipid metabolism …
a public health concern worldwide due to its hepatotoxicity caused by lipid metabolism …
Fetus Exposure to Drugs and Chemicals: A Holistic Overview on the Assessment of Their Transport and Metabolism across the Human Placental Barrier
I Kotta-Loizou, A Pritsa, G Antasouras, SN Vasilopoulos… - Diseases, 2024 - mdpi.com
Background: The placenta exerts a crucial role in fetus growth and development during
gestation, protecting the fetus from maternal drugs and chemical exposure. However …
gestation, protecting the fetus from maternal drugs and chemical exposure. However …
Plasma lipids are dysregulated preceding diagnosis of preeclampsia or delivery of a growth restricted infant
Background Lipids serve as multifunctional metabolites that have important implications for
the pregnant mother and developing fetus. Abnormalities in lipids have emerged as …
the pregnant mother and developing fetus. Abnormalities in lipids have emerged as …
Niemann-Pick Disease Type C (NPDC) by Mutation of NPC1 and NPC2: Aberrant Lysosomal Cholesterol Trafficking and Oxidative Stress
Cholesterol trafficking is initiated by the endocytic pathway and transported from
endo/lysosomes to other intracellular organelles. Deficiencies in cholesterol-sensing and …
endo/lysosomes to other intracellular organelles. Deficiencies in cholesterol-sensing and …
Mice placental ECM components may provide a three-dimensional placental microenvironment
Bioethical limitations impair deeper studies in human placental physiology, then most
studies use human term placentas or murine models. To overcome these challenges, new …
studies use human term placentas or murine models. To overcome these challenges, new …
New Perspectives on Cholesterol and Lipoprotein Metabolism
B De Geest, M Mishra - International Journal of Molecular Sciences, 2023 - mdpi.com
In animals, cholesterol is an essential component of every cellular membrane and is
required for cell membrane integrity. Cholesterol is insoluble in water but is solubilized by …
required for cell membrane integrity. Cholesterol is insoluble in water but is solubilized by …
Using liquid chromatography and mass spectrometry to predict potential biomarkers for missed miscarriage and its metabolic pathways in a tertiary center: A cross …
L Xia, H Zhao, L Shan, X Ma, P An… - International Journal of …, 2024 - Wiley Online Library
Objective To determine and compare the serum metabolites in missed abortion versus
normal early pregnancy using ultra‐high‐performance liquid chromatography and tandem …
normal early pregnancy using ultra‐high‐performance liquid chromatography and tandem …
Characterization of Mitochondrial Heat Shock Protein 60 variants in HEK293 Cells Transformed into Steroidogenic
U Hernández-Arciga, S Olvera-Sánchez… - Medical Research …, 2023 - esmed.org
Introduction: During pregnancy, P4 is essential to maintain the maternal-fetal relationship.
Maternal cholesterol is the main source of P4 production, a process that takes place in the …
Maternal cholesterol is the main source of P4 production, a process that takes place in the …
Developmental sex-specific transcriptomic patterns can be altered by transgenic expression of Uty
KD Rock, L Folts, HC Zierden, R Marx-Rattner, NA Leu… - 2023 - researchsquare.com
The genetic material encoded on X and Y chromosomes provides the foundation by which
biological sex differences are established. Epigenetic regulators expressed on these sex …
biological sex differences are established. Epigenetic regulators expressed on these sex …