[HTML][HTML] DNA methylation: an epigenetic mark of cellular memory
M Kim, J Costello - Experimental & molecular medicine, 2017 - nature.com
DNA methylation is a stable epigenetic mark that can be inherited through multiple cell
divisions. During development and cell differentiation, DNA methylation is dynamic, but …
divisions. During development and cell differentiation, DNA methylation is dynamic, but …
[HTML][HTML] Genetic stability of mesenchymal stromal cells for regenerative medicine applications: a fundamental biosafety aspect
S Neri - International journal of molecular sciences, 2019 - mdpi.com
Mesenchymal stem/stromal cells (MSC) show widespread application for a variety of clinical
conditions; therefore, their use necessitates continuous monitoring of their safety. The risk …
conditions; therefore, their use necessitates continuous monitoring of their safety. The risk …
[HTML][HTML] Therapeutic mesenchymal stem/stromal cells: value, challenges and optimization
M Najar, R Melki, F Khalife, L Lagneaux… - Frontiers in cell and …, 2022 - frontiersin.org
Cellular therapy aims to replace damaged resident cells by restoring cellular and molecular
environments suitable for tissue repair and regeneration. Among several candidates …
environments suitable for tissue repair and regeneration. Among several candidates …
[HTML][HTML] Targeting epigenetic regulatory enzymes for cancer therapeutics: novel small-molecule epidrug development
Y Jin, T Liu, H Luo, Y Liu, D Liu - Frontiers in oncology, 2022 - frontiersin.org
Dysregulation of the epigenetic enzyme-mediated transcription of oncogenes or tumor
suppressor genes is closely associated with the occurrence, progression, and prognosis of …
suppressor genes is closely associated with the occurrence, progression, and prognosis of …
[HTML][HTML] Quality control optimization for minimizing security risks associated with mesenchymal stromal cell-based product development
CLK Rebelatto, LM Boldrini-Leite, DR Daga… - International Journal of …, 2023 - mdpi.com
Mesenchymal stromal cells (MSCs) have been considered a therapeutic strategy in
regenerative medicine because of their regenerative and immunomodulatory properties …
regenerative medicine because of their regenerative and immunomodulatory properties …
Mesenchymal stem cells: the past present and future
The biomedical applications of mesenchymal stem cells (MSCs) have gained expanding
attention over the past three decades. MSCs are easily obtained from various tissue types …
attention over the past three decades. MSCs are easily obtained from various tissue types …
[HTML][HTML] Epigenetic mechanisms in cancer
GO Kumoglu, A Sendemir, MB Tanyolac… - Longhua Chinese …, 2022 - lcm.amegroups.org
This review aims to give a brief summary of the most common epigenetic mechanisms, and
their possible relations with cancer initiation and progression, focusing on the possible …
their possible relations with cancer initiation and progression, focusing on the possible …
[HTML][HTML] Reprogramming of human peripheral blood mononuclear cells into induced mesenchymal stromal cells using non-integrating vectors
W Chen, C Wang, ZX Yang, F Zhang, W Wen… - Communications …, 2023 - nature.com
Mesenchymal stromal cells (MSCs) have great value in cell therapies. The MSC therapies
have many challenges due to its inconsistent potency and limited quantity. Here, we report a …
have many challenges due to its inconsistent potency and limited quantity. Here, we report a …
[HTML][HTML] Chromosome copy number variation in telomerized human bone marrow stromal cells; insights for monitoring safe ex-vivo expansion of adult stem cells
Adult human bone marrow stromal cells (hBMSC) cultured for cell therapy require evaluation
of potency and stability for safe use. Chromosomal aberrations upsetting genomic integrity in …
of potency and stability for safe use. Chromosomal aberrations upsetting genomic integrity in …
[PDF][PDF] Culture Systems and Quality Parameters for Clinical-grade Mesenchymal stromal cells
S Oja - 2020 - helda.helsinki.fi
During the two last decades, mesenchymal stromal cells (MSCs) have been topics of
intensive investigation due to their intriguing characteristics, which make them exciting …
intensive investigation due to their intriguing characteristics, which make them exciting …