Background Neurotropic B vitamins play crucial roles as coenzymes and beyond in the
nervous system. Particularly vitamin B1 (thiamine), B6 (pyridoxine), and B12 (cobalamin) …

The mechanisms of action of the dietary components of the Mediterranean diet are reviewed
in prevention of cardiovascular disease, stroke, age-associated cognitive decline and …

Nutrition is an important lifestyle factor that can modify the risk of future cognitive impairment
and dementia. Some, but not conclusive, evidence (mostly from observational studies and …

We have reviewed the literature and have identified more than 100 diseases or conditions
that are associated with raised concentrations of plasma total homocysteine. The …

Homocysteine (Hcy) metabolism is crucial for regulating methionine availability, protein
homeostasis, and DNA-methylation presenting, therefore, key pathways in post-genomic …

The transsulfuration pathway is a metabolic pathway where transfer of sulfur from
homocysteine to cysteine occurs. The pathway leads to the generation of several sulfur …

Vitamin B12 (cobalamin) is an essential cofactor for two metabolic pathways. It is obtained
principally from food of animal origin. Cobalamin becomes bioavailable through a series of …

An increasing aging population worldwide accounts for a growing share of
noncommunicable diseases (NCDs) of the overall social and economic burden. Dietary and …

It is estimated that the prevalence rate of Alzheimer's disease (AD) will double by the year
2040. Although currently available treatments help with symptom management, they do not …

The microbiota–gut–brain axis plays an important role in the development of
neurodegenerative diseases. Commensal and pathogenic enteric bacteria can influence …