IL-36 is a most recent member of the IL-1 cytokine family, primarily expressed at barrier sites
of the body such as the skin, lungs, and intestine. It plays a vital role in inflammation and is …

Matricellular proteins comprise a diverse group of molecular entities secreted into the
extracellular space. They interact with the extracellular matrix (ECM), integrins, and other …

Interstitial lung disease (ILD) is a frequent extra-articular manifestation of rheumatoid arthritis
(RA) and increases mortality in patients with RA. Early identification of ILD, especially the …

Fibrosis refers to the phenomenon that fibrous connective tissues are increased and
parenchymal cells are decreased in organs or tissues such as lung, heart, liver, kidney, skin …

The oral epithelial barrier acts as both a physical barrier to the abundant oral microbiome
and a sentry for the immune system that, in health, constrains the accumulation of the …

Abstract Interleukin-36 (IL-36) cytokine family members play an immunomodulatory function
to immune cells through IL-36 receptor signaling pathway. However, the regulatory role of IL …

Abstract Background Interleukin-36s (IL-36s) are a category of inflammatory cytokines and
an increasing number of studies over the past decade have found that different kinds of IL …

Interleukin-36 (IL-36) cytokines are structurally similar to other Interleukin-1 superfamily
members and are essential to convey inflammatory responses at epithelial barriers including …

Background Numerous studies have described the critical importance of interleukin (IL)‐36γ
in host defense against lung infections, but it is unknown whether it plays a role in infectious …

Background While numerous allergy-related biomarkers and targeted treatment strategies
have been developed and employed, there are still signifcant limitations and challenges in …