Recent advances in neuropeptide signaling in Drosophila, from genes to physiology and behavior

DR Nässel, M Zandawala - Progress in neurobiology, 2019 - Elsevier
This review focuses on neuropeptides and peptide hormones, the largest and most diverse
class of neuroactive substances, known in Drosophila and other animals to play roles in …

Human disease models in Drosophila melanogaster and the role of the fly in therapeutic drug discovery

UB Pandey, CD Nichols - Pharmacological reviews, 2011 - ASPET
The common fruit fly, Drosophila melanogaster, is a well studied and highly tractable genetic
model organism for understanding molecular mechanisms of human diseases. Many basic …

[HTML][HTML] A connectome of the Drosophila central complex reveals network motifs suitable for flexible navigation and context-dependent action selection

BK Hulse, H Haberkern, R Franconville… - Elife, 2021 - elifesciences.org
Flexible behaviors over long timescales are thought to engage recurrent neural networks in
deep brain regions, which are experimentally challenging to study. In insects, recurrent …

Genomic insights into the Ixodes scapularis tick vector of Lyme disease

M Gulia-Nuss, AB Nuss, JM Meyer… - Nature …, 2016 - nature.com
Ticks transmit more pathogens to humans and animals than any other arthropod. We
describe the 2.1 Gbp nuclear genome of the tick, Ixodes scapularis (Say), which vectors …

Chemoconnectomics: mapping chemical transmission in Drosophila

B Deng, Q Li, X Liu, Y Cao, B Li, Y Qian, R Xu, R Mao… - Neuron, 2019 - cell.com
We define the chemoconnectome (CCT) as the entire set of neurotransmitters,
neuromodulators, neuropeptides, and their receptors underlying chemotransmission in an …

Cellular diversity in the Drosophila midbrain revealed by single-cell transcriptomics

V Croset, CD Treiber, S Waddell - Elife, 2018 - elifesciences.org
To understand the brain, molecular details need to be overlaid onto neural wiring diagrams
so that synaptic mode, neuromodulation and critical signaling operations can be considered …

Functional consequences of neuropeptide and small-molecule co-transmission

MP Nusbaum, DM Blitz, E Marder - Nature Reviews Neuroscience, 2017 - nature.com
Colocalization of small-molecule and neuropeptide transmitters is common throughout the
nervous system of all animals. The resulting co-transmission, which provides conjoint …

[HTML][HTML] Herbal extracts and phytochemicals: plant secondary metabolites and the enhancement of human brain function

DO Kennedy, EL Wightman - Advances in Nutrition, 2011 - Elsevier
Humans consume a wide range of foods, drugs, and dietary supplements that are derived
from plants and which modify the functioning of the central nervous sytem (CNS). The …

Medicinal plants, human health and biodiversity: a broad review

T Sen, SK Samanta - Biotechnological applications of biodiversity, 2015 - Springer
<? xm-replace_text {Heading}?> Abstract Biodiversity contributes significantly towards
human livelihood and development and thus plays a predominant role in the well being of …

A worldwide survey of genome sequence variation provides insight into the evolutionary history of the honeybee Apis mellifera

A Wallberg, F Han, G Wellhagen, B Dahle, M Kawata… - Nature …, 2014 - nature.com
The honeybee Apis mellifera has major ecological and economic importance. We analyze
patterns of genetic variation at 8.3 million SNPs, identified by sequencing 140 honeybee …