Inflammasome Signaling in Atrial Fibrillation: JACC State-of-the-Art Review

A Ajoolabady, S Nattel, GYH Lip, J Ren - Journal of the American College …, 2022 - jacc.org
As the most prevalent form of arrhythmia, atrial fibrillation (AF) increases the risk of heart
failure, thromboembolism, and stroke, contributing to the raising mortality and morbidity in …

Targeting gut microbiota in aging-related cardiovascular dysfunction: Focus on the mechanisms

S Liu, Y He, Y Zhang, Z Zhang, K Huang, L Deng… - Gut …, 2023 - Taylor & Francis
The global population is aging and age-related cardiovascular disease is increasing. Even
after controlling for cardiovascular risk factors, readmission and mortality rates remain high …

[HTML][HTML] Commensal microbe-derived SCFA alleviates atrial fibrillation via GPR43/NLRP3 signaling

K Zuo, C Fang, Z Liu, Y Fu, Y Liu, L Liu… - … Journal of Biological …, 2022 - ncbi.nlm.nih.gov
Rationale: Dysbiotic gut microbiota (GM) and NLRP3 inflammasome are proarrhythmic
factors in atrial fibrillation (AF). Herein, whether short-chain fatty acid (SCFA) produced from …

[HTML][HTML] Gut microbiome and atrial fibrillation—results from a large population-based study

J Palmu, CS Börschel, A Ortega-Alonso, L Markó… - …, 2023 - thelancet.com
Background Atrial fibrillation (AF) is an important heart rhythm disorder in aging populations.
The gut microbiome composition has been previously related to cardiovascular disease risk …

[HTML][HTML] Mechanisms underlying antiarrhythmic properties of cardioprotective agents impacting inflammation and oxidative stress

K Andelova, BS Bacova, M Sykora, P Hlivak… - International Journal of …, 2022 - mdpi.com
The prevention of cardiac life-threatening ventricular fibrillation and stroke-provoking atrial
fibrillation remains a serious global clinical issue, with ongoing need for novel approaches …

[HTML][HTML] Gut microbiota and microbiota-derived metabolites in cardiovascular diseases

X Chen, H Zhang, S Ren, Y Ding… - Chinese Medical …, 2023 - journals.lww.com
Cardiovascular diseases, including heart failure, coronary artery disease, atherosclerosis,
aneurysm, thrombosis, and hypertension, are a great economic burden and threat to human …

Psychological factors and risk of atrial fibrillation: a meta-analysis and systematic review

H Wu, C Li, B Li, T Zheng, K Feng, Y Wu - International journal of cardiology, 2022 - Elsevier
Background Multiple studies have shown that mental disorders are common risk factors for
cardiovascular diseases (CVD). However, the relationship between psychological factors …

Aging and atrial fibrillation: A vicious circle

P Gao, X Gao, B Xie, G Tse, T Liu - International Journal of Cardiology, 2023 - Elsevier
Atrial fibrillation (AF) is the commonest sustained cardiac arrhythmia observed in clinical
practice. Its prevalence increases dramatically with advancing age. This review article …

Disordered gut microbiota promotes atrial fibrillation by aggravated conduction disturbance and unbalanced linoleic acid/SIRT1 signaling

C Fang, K Zuo, Z Liu, Y Liu, L Liu, Y Wang, X Yin… - Biochemical …, 2023 - Elsevier
Emerging evidence suggests an association of dysbiotic gut microbiota (GM) with atrial
fibrillation (AF). The current study aimed to determine whether aberrant GM promotes AF …

[HTML][HTML] Intestinal barrier dysfunction and microbial translocation in patients with first-diagnosed atrial fibrillation

L Blöbaum, M Witkowski, M Wegner, S Lammel… - Biomedicines, 2023 - mdpi.com
Background: According to the leaky gut concept, microbial products (eg, lipopolysaccharide,
LPS) enter the circulation and mediate pro-inflammatory immunological responses. Higher …