The implication of the gut microbiome in heart failure

VV Lupu, A Adam Raileanu, CM Mihai, ID Morariu… - Cells, 2023 - mdpi.com
Heart failure is a worldwide health problem with important consequences for the overall
wellbeing of affected individuals as well as for the healthcare system. Over recent decades …

Local and systemic effects of microbiome‐derived metabolites

I Spivak, L Fluhr, E Elinav - EMBO reports, 2022 - embopress.org
Commensal microbes form distinct ecosystems within their mammalian hosts, collectively
termed microbiomes. These indigenous microbial communities broadly expand the genomic …

The role of branched-chain amino acids and branched-chain α-keto acid dehydrogenase kinase in metabolic disorders

C Du, WJ Liu, J Yang, SS Zhao, HX Liu - Frontiers in Nutrition, 2022 - frontiersin.org
Branched-chain amino acids (BCAAs), composed of leucine, isoleucine, and valine, are
important essential amino acids in human physiology. Decades of studies have revealed …

Psoriasis: Interplay between dysbiosis and host immune system

B Kapoor, M Gulati, P Rani, R Gupta - Autoimmunity reviews, 2022 - Elsevier
With advancement in human microbiome research, an increasing number of scientific
evidences have endorsed the key role of both gut and skin microbiota in the pathogenesis of …

Breaking the barriers: the role of gut homeostasis in Metabolic-Associated Steatotic Liver Disease (MASLD)

R Benedé-Ubieto, FJ Cubero, YA Nevzorova - Gut microbes, 2024 - Taylor & Francis
ABSTRACT Obesity, insulin resistance (IR), and the gut microbiome intricately interplay in
Metabolic-associated Steatotic Liver Disease (MASLD), previously known as Non-Alcoholic …

Potential therapeutic implications of histidine catabolism by the gut microbiota in NAFLD patients with morbid obesity

S Quesada-Vazquez, A Castells-Nobau, J Latorre… - Cell Reports …, 2023 - cell.com
The gut microbiota contributes to the pathophysiology of non-alcoholic fatty liver disease
(NAFLD). Histidine is a key energy source for the microbiota, scavenging it from the host. Its …

Dapagliflozin-affected endothelial dysfunction and altered gut microbiota in mice with heart failure

N Bao, X Liu, X Zhong, S Jia, N Hua, L Zhang, G Mo - PeerJ, 2023 - peerj.com
Aim To investigate the potential microbiome profile of a mouse model with heart failure (HF)
during dapagliflozin treatment. Method An HF model was constructed in 8-week-old male …

Heart failure severity closely correlates with intestinal dysbiosis and subsequent metabolomic alterations

ME Spehlmann, AY Rangrez, DP Dhotre, N Schmiedel… - Biomedicines, 2022 - mdpi.com
Growing evidence suggests an altered gut microbiome in patients with heart failure (HF).
However, the exact interrelationship between microbiota, HF, and its consequences on the …

Gut–Kidney–Heart: A Novel Trilogy

M Caldarelli, L Franza, P Rio, A Gasbarrini… - Biomedicines, 2023 - mdpi.com
The microbiota represents a key factor in determining health and disease. Its role in
inflammation and immunological disorders is well known, but it is also involved in several …

[HTML][HTML] Re-defining the Gut Heart Axis: A Systematic Review of the Literature on the Role of Gut Microbial Dysbiosis in Patients With Heart Failure

D Desai, A Desai, A Jamil, D Csendes, SD Gutlapalli… - Cureus, 2023 - ncbi.nlm.nih.gov
Heart failure (HF) contributes to the cardiovascular health burden worldwide. Patients with
heart failure have been recently studied to possess unique changes in the gut microbiome …