Interstitial lung diseases

M Wijsenbeek, A Suzuki, TM Maher - The Lancet, 2022 - thelancet.com
Over 200 interstitial lung diseases, from ultra rare to relatively common, are recognised.
Most interstitial lung diseases are characterised by inflammation or fibrosis within the …

Pulmonary fibrosis, part I: epidemiology, pathogenesis, and diagnosis

KC Meyer - Expert review of respiratory medicine, 2017 - Taylor & Francis
Introduction: Many forms of interstitial lung disease (ILD) can progress to extensive fibrosis
and respiratory failure. Idiopathic pulmonary fibrosis (IPF), which generally has a poor …

Lung cancer in patients with idiopathic pulmonary fibrosis

T Karampitsakos, V Tzilas, R Tringidou… - Pulmonary …, 2017 - Elsevier
Idiopathic pulmonary fibrosis (IPF) is a chronic fibrotic lung disease of unknown etiology.
With a gradually increasing worldwide prevalence and a mortality rate exceeding that of …

[HTML][HTML] Blood biomarkers in idiopathic pulmonary fibrosis

J Guiot, C Moermans, M Henket, JL Corhay, R Louis - Lung, 2017 - Springer
Purpose Idiopathic pulmonary fibrosis (IPF) is a progressive and lethal lung disease of
unknown origin whose incidence has been increasing over the latest decade partly as a …

Novel autotaxin inhibitor for the treatment of idiopathic pulmonary fibrosis: a clinical candidate discovered using DNA-encoded chemistry

JW Cuozzo, MA Clark, AD Keefe… - Journal of Medicinal …, 2020 - ACS Publications
The activity of the secreted phosphodiesterase autotaxin produces the inflammatory
signaling molecule LPA and has been associated with a number of human diseases …

[HTML][HTML] Genetics in idiopathic pulmonary fibrosis pathogenesis, prognosis, and treatment

A Kaur, SK Mathai, DA Schwartz - Frontiers in medicine, 2017 - frontiersin.org
Idiopathic pulmonary fibrosis (IPF), the most common form of idiopathic interstitial
pneumonia (IIP), is characterized by irreversible scarring of the lung parenchyma and …

A phase 2 randomized controlled study of tralokinumab in subjects with idiopathic pulmonary fibrosis

JM Parker, IN Glaspole, LH Lancaster… - American journal of …, 2018 - atsjournals.org
Rationale: IL-13 is a potential therapeutic target for idiopathic pulmonary fibrosis (IPF);
preclinical data suggest a role in tissue fibrosis, and expression is increased in subjects with …

[HTML][HTML] Exosomal miR-17-5p from human embryonic stem cells prevents pulmonary fibrosis by targeting thrombospondin-2

Q Liu, Y Bi, S Song, K Zhu, X Qiao, H Wang… - Stem Cell Research & …, 2023 - Springer
Background Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, and irreversible
lung disease characterized by pulmonary fibrosis and lung dysfunction, ultimately leading to …

[HTML][HTML] Evaluating disease severity in idiopathic pulmonary fibrosis

H Robbie, C Daccord, F Chua… - European Respiratory …, 2017 - Eur Respiratory Soc
Accurate assessment of idiopathic pulmonary fibrosis (IPF) disease severity is integral to the
care provided to patients with IPF. However, to date, there are no generally accepted or …

CYFRA 21-1 predicts progression in idiopathic pulmonary fibrosis: a prospective longitudinal analysis of the PROFILE cohort

PL Molyneaux, WA Fahy, AJ Byrne… - American journal of …, 2022 - atsjournals.org
Rationale: Idiopathic pulmonary fibrosis (IPF) is a progressive and inevitably fatal condition
for which there are a lack of effective biomarkers to guide therapeutic decision making …