[HTML][HTML] Peptides for optical medical imaging and steps towards therapy

M Staderini, A Megia-Fernandez, K Dhaliwal… - Bioorganic & medicinal …, 2018 - Elsevier
Optical medical imaging is a rapidly growing area of research and development that offers a
multitude of healthcare solutions both diagnostically and therapeutically. In this review …

A multifunctional probe with aggregation-induced emission characteristics for selective fluorescence imaging and photodynamic killing of bacteria over mammalian …

M Gao, Q Hu, G Feng, N Tomczak, R Liu… - Advanced healthcare …, 2014 - europepmc.org
A multifunctional probe aggregation-induced emission-Zinc (II)-dipicolylamine (AIE-ZnDPA)
is developed for selective targeting, fluorescence imaging, and photodynamic killing of both …

Development and prospects of dedicated tracers for the molecular imaging of bacterial infections

A Bunschoten, MM Welling, MF Termaat… - Bioconjugate …, 2013 - ACS Publications
Bacterial infections have always been, and still are, a major global healthcare problem. For
accurate treatment it is of upmost importance that the location (s), severity, type of bacteria …

Near-infrared dyes: probe development and applications in optical mole-cular imaging

DD Nolting, JC Gore, W Pham - Current organic synthesis, 2011 - ingentaconnect.com
The recent emergence of optical imaging has brought forth a unique challenge for chemists:
development of new biocompatible dyes that fluoresce in the near-infrared (NIR) region for …

Infection imaging with 18F-FDS and first-in-human evaluation

S Yao, H Xing, W Zhu, Z Wu, Y Zhang, Y Ma… - Nuclear medicine and …, 2016 - Elsevier
Purpose The noninvasive imaging of bacterial infections is critical in order to reduce
mortality and morbidity caused by these diseases. The recently reported 18 F-FDS (18 F-2 …

A turn-on NIR fluorescence and colourimetric cyanine probe for monitoring the thiol content in serum and the glutathione reductase assisted glutathione redox process

D Maity, T Govindaraju - Organic & biomolecular chemistry, 2013 - pubs.rsc.org
We report a novel reaction-based thiol selective turn-on near-infrared (NIR) fluorescence
and colourimetric dinitrobenzenesulfonyl-cyanine (DNBSCy) probe. In the presence of thiols …

Optical imaging of bacterial infection in living mice using deep-red fluorescent squaraine rotaxane probes

AG White, N Fu, WM Leevy, JJ Lee… - Bioconjugate …, 2010 - ACS Publications
Two structurally related fluorescent imaging probes allow optical imaging of bacterial leg
infection models in living athymic and immunocompetent mice. Structurally, the probes are …

Replacement, refinement, and reduction in animal studies with biohazardous agents

LV Kendall, JR Owiny, ED Dohm, KJ Knapek… - ILAR …, 2018 - academic.oup.com
Animal models are critical to the advancement of our knowledge of infectious disease
pathogenesis, diagnostics, therapeutics, and prevention strategies. The use of animal …

Validation of 2-18F-fluorodeoxysorbitol as a potential radiopharmaceutical for imaging bacterial infection in the lung

J Li, H Zheng, R Fodah, JM Warawa… - Journal of Nuclear …, 2018 - Soc Nuclear Med
2-18F-fluorodeoxysorbitol (18F-FDS) has been shown to be a promising agent with high
selectivity and sensitivity in imaging bacterial infection. The objective of our study was to …

Bacterial vectors for imaging and cancer gene therapy: a review

M Cronin, RM Stanton, KP Francis, M Tangney - Cancer gene therapy, 2012 - nature.com
The significant burden of resistance to conventional anticancer treatments in patients with
advanced disease has prompted the need to explore alternative therapeutic strategies. The …