miRNAs as biomarkers in disease: latest findings regarding their role in diagnosis and prognosis

CE Condrat, DC Thompson, MG Barbu, OL Bugnar… - Cells, 2020 - mdpi.com
MicroRNAs (miRNAs) represent a class of small, non-coding RNAs with the main roles of
regulating mRNA through its degradation and adjusting protein levels. In recent years …

MicroRNA as an important target for anticancer drug development

Z Fu, L Wang, S Li, F Chen, KKW Au-Yeung… - Frontiers in …, 2021 - frontiersin.org
Cancer has become the second greatest cause of death worldwide. Although there are
several different classes of anticancer drugs that are available in clinic, some tough issues …

One DNA circle capture probe with multiple target recognition domains for simultaneous electrochemical detection of miRNA-21 and miRNA-155

S Xu, Y Chang, Z Wu, Y Li, R Yuan, Y Chai - Biosensors and Bioelectronics, 2020 - Elsevier
In this work, a novel DNA circle capture probe with multiple target recognition domains was
designed to develop an electrochemical biosensor for ultrasensitive detection of microRNA …

MicroRNA as a novel biomarker in the diagnosis of head and neck cancer

J Kabzinski, M Maczynska, I Majsterek - Biomolecules, 2021 - mdpi.com
Head and neck squamous cell carcinoma is the sixth most common cancer worldwide, with
890,000 new cases and 450,000 deaths in 2018, and although the survival statistics for …

Cervical cancer, papillomavirus, and miRNA dysfunction

EG Bañuelos-Villegas, MF Pérez-yPérez… - Frontiers in Molecular …, 2021 - frontiersin.org
Cervical cancer is the leading cause of death by cancer in women from developing
countries. Persistent infection with high-risk human papillomavirus (HPV) types 16 and 18 is …

Faraday-cage-type electrochemiluminescence immunoassay: a rise of advanced biosensing strategy

P Kannan, J Chen, F Su, Z Guo, Y Huang - Analytical chemistry, 2019 - ACS Publications
Electrochemiluminescence immunoassays are usually carried out through “on-electrode”
strategy, ie, sandwich-type immunoassay format, the sensitivity of which is restricted by two …

Efficient and exponential rolling circle amplification molecular network leads to ultrasensitive and label-free detection of MicroRNA

D Li, T Zhang, F Yang, R Yuan, Y Xiang - Analytical chemistry, 2019 - ACS Publications
MicroRNAs (miRNAs) are useful biomarkers for the diagnosis of a variety of cancers.
However, it is a major challenge to detect miRNAs, considering their high sequence …

[HTML][HTML] Recent advances on the molecular mechanism of cervical carcinogenesis based on systems biology technologies

M Lin, M Ye, J Zhou, ZP Wang, X Zhu - Computational and Structural …, 2019 - Elsevier
Cervical cancer is one of the common malignancies in women worldwide. Exploration of
pathogenesis and molecular mechanism of cervical cancer is pivotal for development of …

Bioinformatic analysis reveals an exosomal miRNA-mRNA network in colorectal cancer

J Ma, P Wang, L Huang, J Qiao, J Li - BMC medical genomics, 2021 - Springer
Background Exosomes play important roles in angiogenesis, drug resistance, and
metastasis of colorectal cancer (CRC), but the underlying mechanism has seldom been …

The pathological risk score: a new deep learning‐based signature for predicting survival in cervical cancer

C Chen, Y Cao, W Li, Z Liu, P Liu, X Tian… - Cancer …, 2023 - Wiley Online Library
Purpose To develop and validate a deep learning‐based pathological risk score (RS) with
an aim of predicting patients' prognosis to investigate the potential association between the …