Mitochondria, the 'powerhouse'of eukaryotic cells, play a key role in cellular homeostasis.
However, defective mitochondria increase mitochondrial ROS (mtROS) production and cell …

Evidence supports a strong bidirectional association between depression and Type 2
diabetes mellitus (T2DM). The harmful impact of oxidative stress and chronic inflammation …

Background Some evidence suggests that depression is more common in obese patients.
This fact gives us a hint that obesity might be a promoter of depression, though a conclusion …

Various exercise-training types are known to prevent depression, but mechanisms
underlying their beneficial effects remain unknown. In the present study, the preconditioning …

Background Previous studies have shown that depression is often accompanied by an
increase in mtDNA copy number and a decrease in ATP levels; however, the exact …

Depression is gradually becoming a primary mental disease threatening human health.
Therefore, there is an urgent need to clarify the pathogenesis of depression and identify new …

(1) Background: Depression is one of the overwhelming public health problems. Alleviating
hippocampus injury may prevent depression development. Herein, we established the …

Background Depression is a global disease that affects the physical and mental health of
people of all ages. Non-pharmacological and unconventional methods of treatment, such as …

Chronic stress induces neuronal death and impairs hippocampal neurogenesis, thus
leading to cognitive deficits and depressive-like behaviors. Our previous studies found that …

Besides significant benefits to physical health, exercise promotes mental health, reduces
symptoms of mental illness, and enhances psychological development. Exercise can offset …