Abstract The Hedgehog (Hh) signaling pathway was first identified in the common fruit fly. It
is a highly conserved evolutionary pathway of signal transmission from the cell membrane to …

Vitamin D has a key role in stimulating calcium absorption from the gut and promoting
skeletal health, as well as many other important physiological functions. Vitamin D is …

Epithelial-to-mesenchymal transition (EMT) is a key step in development, wound healing,
and cancer development. It involves cooperation of signaling pathways, such as …

The epithelial components of the mammary gland are thought to arise from stem cells with a
capacity for self-renewal and multilineage differentiation. Furthermore, these cells and/or …

The developmentally important Hedgehog (Hh) signaling pathway has recently been
implicated in several forms of solid cancer. Current drug development programs focus on …

The Hedgehog (Hh) pathway is activated in some human cancers, including
medulloblastoma. The glioma-associated oncogene homolog (GLI) transcription factors are …

Chemical modifications of RNA molecules regulate both RNA metabolism and fate. The
deposition and function of these modifications are mediated by the actions of writer, reader …

Constitutive activation of the Hedgehog (Hh) signaling pathway is associated with increased
risk of developing several malignancies. The biological and pathogenic importance of Hh …

Prostate cancer is the most common solid tumor in men, and it shares with all cancers the
hallmark of elevated, nonhomeostatic cell proliferation. Here we have tested the hypothesis …

The keratinocytes of the skin are unique in being not only the primary source of vitamin D for
the body, but in possessing both the enzymatic machinery to metabolize the vitamin D …