Substance use disorder, especially in relation to opioids such as heroin and fentanyl, is a
significant public health issue and has intensified in recent years. As a result, substantial …

The majority of vaccines have been delivered into the muscular tissue. Skin contains large
amounts of antigen-presenting cells and has been recognized as a more immunogenic site …

Heroin is a highly abused opioid and incurs a significant detriment to society worldwide. In
an effort to expand the limited pharmacotherapy options for opioid use disorders, a heroin …

A potent adjuvant that induces strong protective immunity without incurring any significant
skin reactogenicity is urgently needed for cutaneous vaccination. Here, we report that a …

The biosafety of sericin remains controversial. The misunderstanding regarding sericin
causing adverse biological responses have been clarified by extensively reviewing relevant …

Vaccines delivered to the skin by microneedles—with and without adjuvants—have
increased immunogenicity with lower doses than standard vaccine delivery techniques such …

The current study details efficient lesion-free cutaneous vaccination via vaccine delivery into
an array of micropores in the skin, instead of bolus injection at a single site. Such delivery …

There is an urgent need for the rational design of safe and effective vaccines to protect
against chronic bacterial pathogens such as Mycobacterium tuberculosis. Advax™ is a …

Active immunization is an effective means of blocking the pharmacodynamic effects of drugs
and holds promise as a treatment for heroin addiction. Previously, we demonstrated the …

Clinical trials of nicotine vaccines suggest that they can enhance smoking cessation rates
but do not reliably produce the consistently high serum antibody concentrations required. A …