Epilepsy is a chronic disease that affects millions of people worldwide. Antiepileptic drugs
(AEDs) are used to control seizures. Even though parts of their mechanisms of action are …

Abstract Lipoic acid (α-LA)(1, 2-dithiolane3-pentanoic acid (C8H14O2S2) is also called
thioctic acid with an oxidized (disulfide, LA) and a reduced (di-thiol: dihydro-lipoic acid …

Mild deficits in mitochondrial function have been shown to increase lifespan in multiple
species including worms, flies and mice. Here, we study three C. elegans mitochondrial …

In the past century, noncommunicable diseases have surpassed infectious diseases as the
principal cause of sickness and death, worldwide. Trillions of commensal microbes live in …

Curcumin has extensive therapeutic potential because of its antioxidant, anti‐inflammatory,
and antiproliferative properties. Multiple preclinical studies in vitro and in vivo have proven …

Herein we trace links between biochemical pathways, pathogenesis, and metabolic
diseases to set the stage for new therapeutic advances. Cellular and acellular …

Neurological disorders are increasing at a faster pace due to oxidative stress, protein
aggregation, excitotoxicity, and neuroinflammation. It is reported that the Mediterranean diet …

The aging process comprises a series of organic alterations, affecting multiple systems,
including the nervous system. Aging has been considered the main risk factor for the …

Mitochondria are dynamic double-membrane bound organelles which have key roles in a
variety of cellular functions such as energy producing, regulation of calcium flux, cellular …

Pathological deterioration of mitochondrial function is increasingly linked with multiple
degenerative illnesses as a mediator of a wide range of neurologic and age-related chronic …