Over the past decade, the immune system has emerged as an important component in the
aetiology of hypertension. There has been a blooming interest in the contribution of the gut …

Abstract Cardiometabolic disorders are chief causes of morbidity and mortality, with chronic
inflammation playing a crucial role in their pathogenesis. The release of differentiated …

Neutrophils, the most abundant of all leucocytes and the first cells to arrive at the sites of
sterile inflammation/injury act as a double-edged sword. On one hand, they inflict a …

Inflammation is an important driver of atherosclerosis, and the favourable outcomes of the
Canakinumab Anti-inflammatory Thrombosis Outcome Study (CANTOS) trial revealed the …

Inflammation represents the driving feature of many diseases, including atherosclerosis,
cancer, autoimmunity and infections. It is now established that metabolic processes shape a …

Monocytes are critical mediators of the inflammatory response following myocardial
infarction (MI) and ischemia-reperfusion injury. They are involved in both initiation and …

Trained immunity is one of the mechanisms by which BCG vaccination confers persistent
nonspecific protection against diverse diseases. Genomic differences between the different …

Recent advances in immunology and cancer research show that fatty acids, their
metabolism and their sensing have a crucial role in the biology of many different cell types …

Trained innate immunity describes the metabolic reprogramming and long-term
proinflammatory activation of innate immune cells in response to different pathogen or …

Atherosclerosis is the major cause of cardiovascular disease (CVD). Monocyte-derived
macrophages are the most abundant immune cells in atherosclerotic plaques. In patients …