Engineering precision nanoparticles for drug delivery

MJ Mitchell, MM Billingsley, RM Haley… - Nature reviews drug …, 2021 - nature.com
In recent years, the development of nanoparticles has expanded into a broad range of
clinical applications. Nanoparticles have been developed to overcome the limitations of free …

Toward nanotechnology-enabled approaches against the COVID-19 pandemic

C Weiss, M Carriere, L Fusco, I Capua… - ACS …, 2020 - ACS Publications
The COVID-19 outbreak has fueled a global demand for effective diagnosis and treatment
as well as mitigation of the spread of infection, all through large-scale approaches such as …

Antibacterial action of nanoparticles by lethal stretching of bacterial cell membranes

DP Linklater, VA Baulin, X Le Guével… - Advanced …, 2020 - Wiley Online Library
It is commonly accepted that nanoparticles (NPs) can kill bacteria; however, the mechanism
of antimicrobial action remains obscure for large NPs that cannot translocate the bacterial …

[HTML][HTML] Polymeric micellar systems—a special emphasis on “smart” drug delivery

I Negut, B Bita - Pharmaceutics, 2023 - mdpi.com
Concurrent developments in anticancer nanotechnological treatments have been observed
as the burden of cancer increases every year. The 21st century has seen a transformation in …

[HTML][HTML] Toxicity of manufactured nanomaterials

Y Liu, S Zhu, Z Gu, C Chen, Y Zhao - Particuology, 2022 - Elsevier
Manufactured nanomaterials with unique properties have been extensively applied in
various industrial, agricultural or medical fields. However, some of the properties have been …

Mechanistic understanding from molecular dynamics simulation in pharmaceutical research 1: drug delivery

A Bunker, T Róg - Frontiers in Molecular Biosciences, 2020 - frontiersin.org
In this review, we outline the growing role that molecular dynamics simulation is able to play
as a design tool in drug delivery. We cover both the pharmaceutical and computational …

Graphene oxide nanosheets interact and interfere with SARS‐CoV‐2 surface proteins and cell receptors to inhibit infectivity

MA Unal, F Bayrakdar, H Nazir, O Besbinar, C Gurcan… - Small, 2021 - Wiley Online Library
Nanotechnology can offer a number of options against coronavirus disease 2019 (COVID‐
19) acting both extracellularly and intracellularly to the host cells. Here, the aim is to explore …

Review of photoresponsive plasmonic nanoparticles that produce reactive chemical species for photodynamic therapy of cancer and bacterial infections

SK Singh, S Mazumder, A Vincy… - ACS Applied Nano …, 2023 - ACS Publications
Increased use of classical drug therapy, including the administration of antibiotics and
anticancer drugs, has led to multidrug resistance. Overcoming this resistance requires …

Toxic effects and involved molecular pathways of nanoparticles on cells and subcellular organelles

N Liu, M Tang - Journal of Applied Toxicology, 2020 - Wiley Online Library
Owing to the increasing application of engineered nanoparticles (NPs), besides the
workplace, human beings are also exposed to NPs from nanoproducts through the skin …

Integration of in vitro and in vivo models to predict cellular and tissue dosimetry of nanomaterials using physiologically based pharmacokinetic modeling

Z Lin, S Aryal, YH Cheng, AJ Gesquiere - ACS nano, 2022 - ACS Publications
Nanomaterials (NMs) have been increasingly used in a number of areas, including
consumer products and nanomedicine. Target tissue dosimetry is important in the evaluation …