Kindlin-2 haploinsufficiency protects against fatty liver by targeting Foxo1 in mice

H Gao, L Zhou, Y Zhong, Z Ding, S Lin, X Hou… - Nature …, 2022 - nature.com
Nonalcoholic fatty liver disease (NAFLD) affects a large population with incompletely
defined mechanism (s). Here we report that Kindlin-2 is dramatically up-regulated in livers in …

Thioredoxin/glutaredoxin systems and gut microbiota in NAFLD: interplay, mechanism, and therapeutical potential

M Zhu, OMA Dagah, BB Silaa, J Lu - Antioxidants, 2023 - mdpi.com
Non-alcoholic fatty liver disease (NAFLD) is a common clinical disease, and its
pathogenesis is closely linked to oxidative stress and gut microbiota dysbiosis. Recently …

COVID-19 infection and body weight: A deleterious liaison in a J-curve relationship

AS Manolis, AA Manolis, TA Manolis… - Obesity Research & …, 2021 - Elsevier
During the course of the COVID-19 pandemic, obesity has been shown to be an
independent risk factor for high morbidity and mortality. Obesity confers poor outcomes in …

[HTML][HTML] Novel strategies for glycaemic control and preventing diabetic complications applying the clustering-based classification of adult-onset diabetes mellitus: a …

H Tanabe, H Masuzaki, M Shimabukuro - Diabetes research and clinical …, 2021 - Elsevier
Diabetes mellitus results from an interplay between insulin resistance and β-cell dysfunction.
Since their relative contributions to its pathogenesis are difficult to quantify, therapeutic …

Role of agents for the treatment of diabetes in the management of nonalcoholic fatty liver disease

J Budd, K Cusi - Current diabetes reports, 2020 - Springer
Abstract Purpose of Review Nonalcoholic fatty liver disease (NAFLD) is an often
unrecognized complication of type 2 diabetes (T2DM) associated with significant economic …

Pioglitazone and bariatric surgery are the most effective treatments for non‐alcoholic steatohepatitis: A hierarchical network meta‐analysis

S Panunzi, S Maltese, O Verrastro… - Diabetes, Obesity …, 2021 - Wiley Online Library
Aims To compare different treatments for non‐alcoholic steatohepatitis (NASH) and to
determine an effectiveness hierarchy. Materials and Methods We conducted a systematic …

[HTML][HTML] Microbiota-induced lipid peroxidation impairs obeticholic acid-mediated antifibrotic effect towards nonalcoholic steatohepatitis in mice

A Zhuge, S Li, Y Yuan, S Han, J Xia, Q Wang, S Wang… - Redox Biology, 2023 - Elsevier
Obeticholic acid (OCA) has been examined to treat non-alcoholic steatohepatitis (NASH),
but has unsatisfactory antifibrotic effect and deficient responsive rate in recent phase III …

Non-alcoholic fatty liver disease is not a causal risk factor for psoriasis: A Mendelian randomization study of 108,835 individuals

C Näslund-Koch, SE Bojesen, LL Gluud… - Frontiers in …, 2022 - frontiersin.org
Background Psoriasis is observationally associated with a higher risk of non-alcoholic fatty
liver disease (NAFLD); however, the causal relationship between the two diseases remains …

The efficacy of vitamin E in reducing non-alcoholic fatty liver disease: a systematic review, meta-analysis, and meta-regression

M Abdel-Maboud, A Menshawy… - Therapeutic …, 2020 - journals.sagepub.com
Background: Non-alcoholic fatty liver disease (NAFLD) affects up to 30% of the population.
Clinical trials have questioned the role of vitamin E in the treatment of NAFLD with or without …

Preparing for the NASH epidemic: a call to action

F Kanwal, JH Shubrook, Z Younossi, Y Natarajan… - Metabolism, 2021 - Elsevier
Nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) are
common conditions with a rising burden. Yet there are significant management gaps …