Metastasis is responsible for most cancer-associated deaths. Accumulating evidence based
on 3D migration models has revealed a diversity of invasive migratory schemes reflecting …

The ability to degrade extracellular matrix is critical for tumor cells to invade and
metastasize. Recent studies show that tumor cells use specialized actin-based membrane …

A critical step in breast cancer progression is local tissue invasion, during which cells pass
from the epithelial compartment to the stromal compartment. We recently showed that …

Matrix metalloproteinases (MMPs) are a family of zinc endopeptidases that cleave nearly all
components of the extracellular matrix as well as many other soluble and cellassociated …

Unraveling the mechanisms that govern the formation and function of invadopodia is
essential towards the prevention of cancer spread. Here, we characterize the ultrastructural …

Matrix metalloproteinases (MMPs) are the most prominent proteinases involved in
tumorigenesis. They were initially recognized to promote tumor progression by remodeling …

Cancer cells' ability to migrate through constricting pores in the tissue matrix is limited by
nuclear stiffness. MT1-MMP contributes to metastasis by widening matrix pores, facilitating …

Invasion of cancer cells into collagen-rich extracellular matrix requires membrane-tethered
membrane type 1–matrix metalloproteinase (MT1-MMP) as the key protease for collagen …

High insulin/IGF is a biologic link between diabetes and cancers, but the underlying
molecular mechanism remains unclear. Here we report a previously unrecognized tumour …

In solid tumours, cancer cells that undergo epithelial mesenchymal transition (EMT) express
characteristic gene expression signatures that promote invasive migration as well as the …