The mitogen-activated protein kinase (MAPK) signaling pathway is the primary regulatory
module of various cellular processes such as cell proliferation, differentiation, and stress …

c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinase (MAPK) family
members integrate signals that affect proliferation, differentiation, survival, and migration in a …

Cancer is a leading cause of death worldwide. In many cases, the treatment of the disease is
limited due to the metastasis of cells to distant locations of the body through the blood and …

Ethnopharmacological relevance Plant essential oils (PEOs) extracted from aromatic
compounds of the plant contain complex mixtures of volatile and lipophilic bioactive …

Psoriasis is a common, chronic, and inflammatory skin disease with a high burden on
individuals, health systems, and society worldwide. With the immunological pathologies and …

Emodin is a natural occurring anthraquinone derivative isolated from roots and barks of
numerous plants, molds, and lichens. It is found to be an active ingredient in different …

Abstract Ethnopharmacological relevance The Qi-Qin-Hu-Chang Formula (QQHCF) is a
traditional Chinese medicine prescription that is clinically used at the Affiliated Hospital of …

Endogenous glucocorticoids (GCs) are steroid hormones that signal in virtually all cell types
to modulate tissue homeostasis throughout life. Also, synthetic GC derivatives …

SRC homology 3 (SH3) domains are fundamental modules that enable the assembly of
protein complexes through physical interactions with a pool of proline-rich/noncanonical …

Targeted therapies against cancer have improved both survival and quality of life of patients.
However, metabolic rewiring evokes cellular mechanisms that reduce therapeutic …