Polymerization of actin filaments against membranes produces force for numerous cellular
processes, such as migration, morphogenesis, endocytosis, phagocytosis and organelle …

Actin plays many well-known roles in cells, and understanding any specific role is often
confounded by the overlap of multiple actin-based structures in space and time. Here, we …

Cortactin coactivates Arp2/3 complex synergistically with WASP-family nucleation-promoting
factors (NPFs) and stabilizes branched networks by linking Arp2/3 complex to F-actin. It is …

Actin is among the most abundant proteins in eukaryotic cells and assembles into dynamic
filamentous networks regulated by many actin binding proteins. The actin cytoskeleton must …

Exosomes carry and transmit signaling molecules used for intercellular communication. The
generation and secretion of exosomes is a multistep interlocking process that allows …

We reconstructed the structure of actin filament branch junctions formed by fission yeast
Arp2/3 complex at 3.5 Å resolution from images collected by electron cryo-microscopy …

Actin-associated proteins (AAPs) act on monomeric globular actin (G-actin) and polymerized
filamentous actin (F-actin) to regulate their dynamics and architectures which ultimately …

Branched actin networks have emerged as major force-generating structures driving the
protrusions in various distinct cell types and processes, ranging from lamellipodia operating …

Arp2/3 complex generates branched actin networks that drive fundamental processes such
as cell motility and cytokinesis. The complex comprises seven proteins, including actin …

Methionine (Met) can be oxidized to methionine sulfoxide (MetO), which exist as R-and S-
diastereomers. Present in all three domains of life, methionine sulfoxide reductases (MSR) …