Hyperpolarization-activated cyclic nucleotide–gated (HCN) channels are expressed as four
different isoforms (HCN1-4) in the heart and in the central and peripheral nervous systems …

Background Hyperpolarization-activated cyclic nucleotide-gated (HCN) current reduces
dendritic summation, suppresses dendritic calcium spikes, and enables inhibitory GABA …

Neuronal activity is emerging as a driver of central and peripheral nervous system cancers.
Here, we examined neuronal physiology in mouse models of the tumor predisposition …

Neuropathic pain can result from injury to, or disease of the nervous system. It is notoriously
difficult to treat. Peripheral nerve injury promotes Schwann cell activation and invasion of …

Accumulating evidence indicates that there are substantial species differences in the
properties of mammalian neurons, yet theories on circuit activity and information processing …

Brain-state transitions are readily apparent from changes in brain rhythms, but are difficult to
predict, suggestive that the underlying cause is latent to passive recording methods. Among …

Hyperpolarization-activation cyclic nucleotide-gated (HCN) channels were for the first time
implicated in absence seizures (ASs) when an abnormal I h (the current generated by these …

Alzheimer's disease (AD) and Parkinson's disease (PD) represent the most prevalent
neurodegenerative disorders severely impacting life expectancy and quality of life of millions …

Background and Purpose Parvalbumin (PV)‐positive neurons are a type of neuron in the
lateral globus pallidus (LGP) which plays an important role in motor control. The present …

The cAMP-signaling cancers, which are defined by functionally-significant somatic mutations
in one or more elements of the cAMP signaling pathway, have an unexpectedly wide range …