During aging, the cellular milieu of the brain exhibits tell-tale signs of compromised
bioenergetics, impaired adaptive neuroplasticity and resilience, aberrant neuronal network …

Physical exercise (PE) improves physical performance, mental status, general health, and
well-being. It does so by affecting many mechanisms at the cellular and molecular level. PE …

Peroxisome proliferator activated receptor alpha (PPAR-α) belongs to the family of ligand-
regulated nuclear receptors (PPARs). These receptors after heterodimerization with retinoid …

Hormesis refers to adaptive responses of biological systems to moderate environmental or
self-imposed challenges through which the system improves its functionality and/or …

Melatonin, more commonly known as the sleep hormone, is mainly secreted by the pineal
gland in dark conditions and regulates the circadian rhythm of the organism. Its intrinsic …

In order to better understand the pathogenesis of Parkinson's Disease (PD) it is important to
consider possible contributory factors inherent to the aging process, as age-related changes …

Endocannabinoids (eCBs) are amongst the most ubiquitous signaling molecules in the
nervous system. Over the past few decades, observations based on a large volume of work …

Brain cells normally respond adaptively to oxidative stress or bioenergetic challenges,
resulting from ongoing activity in neuronal circuits. During aging and in neurodegenerative …

Biological aging is an inevitable and independent risk factor for a wide array of chronic
diseases including cardiovascular and metabolic diseases. Ample evidence has established …

The past two decades have witnessed remarkable advances in oxidative stress research,
particularly in the context of ischemic brain injury. Oxidative stress in ischemic tissues …