Mitochondrial dysfunction and neurological disorders: a narrative review and treatment overview

EE Alshial, MI Abdulghaney, AHS Wadan… - Life Sciences, 2023 - Elsevier
Mitochondria play a vital role in the nervous system, as they are responsible for generating
energy in the form of ATP and regulating cellular processes such as calcium (Ca 2+) …

Intermittent fasting and cognitive performance–Targeting BDNF as potential strategy to optimise brain health

K Seidler, M Barrow - Frontiers in neuroendocrinology, 2022 - Elsevier
Aging is the major risk factor for neurodegenerative diseases, accelerated by excessive
calorie consumption and sedentary lifestyles. Bioenergetic challenges such as intermittent …

In pursuit of healthy aging: effects of nutrition on brain function

TM Melzer, LM Manosso, S Yau, J Gil-Mohapel… - International journal of …, 2021 - mdpi.com
Consuming a balanced, nutritious diet is important for maintaining health, especially as
individuals age. Several studies suggest that consuming a diet rich in antioxidants and anti …

Energy metabolism decline in the aging brain—pathogenesis of neurodegenerative disorders

JW Błaszczyk - Metabolites, 2020 - mdpi.com
There is a growing body of evidencethat indicates that the aging of the brain results from the
decline of energy metabolism. In particular, the neuronal metabolism of glucose declines …

The role of mitochondria in axon development and regeneration

GM Smith, G Gallo - Developmental neurobiology, 2018 - Wiley Online Library
Mitochondria are dynamic organelles that undergo transport, fission, and fusion. The three
main functions of mitochondria are to generate ATP, buffer cytosolic calcium, and generate …

Guidelines on experimental methods to assess mitochondrial dysfunction in cellular models of neurodegenerative diseases

NMC Connolly, P Theurey, V Adam-Vizi… - Cell Death & …, 2018 - nature.com
Neurodegenerative diseases are a spectrum of chronic, debilitating disorders characterised
by the progressive degeneration and death of neurons. Mitochondrial dysfunction has been …

Serotonin regulates mitochondrial biogenesis and function in rodent cortical neurons via the 5-HT2A receptor and SIRT1–PGC-1α axis

SE Fanibunda, S Deb, B Maniyadath… - Proceedings of the …, 2019 - National Acad Sciences
Mitochondria in neurons, in addition to their primary role in bioenergetics, also contribute to
specialized functions, including regulation of synaptic transmission, Ca2+ homeostasis …

Mitochondrial dysfunction: a potential therapeutic target to treat Alzheimer's disease

SN Rai, C Singh, A Singh, MP Singh, BK Singh - Molecular Neurobiology, 2020 - Springer
Mitochondrial dysfunction plays a very vital role in the pathogenesis of Alzheimer's disease
(AD). Several shreds of evidence have indicated that the mitochondrial function is severely …

Mitochondria in neuronal health: from energy metabolism to Parkinson's disease

H Murali Mahadevan, A Hashemiaghdam… - Advanced …, 2021 - Wiley Online Library
Mitochondria are the main suppliers of neuronal adenosine triphosphate and play a critical
role in brain energy metabolism. Mitochondria also serve as Ca2+ sinks and anabolic …

[HTML][HTML] Novel molecular mechanisms for the adaptogenic effects of herbal extracts on isolated brain cells using systems biology

A Panossian, EJ Seo, T Efferth - Phytomedicine, 2018 - Elsevier
Introduction Adaptogens are natural compounds or plant extracts that increase adaptability
and survival of organisms under stress. Adaptogens stimulate cellular and organismal …