Evaluation of behavior and cognition in rodent models underpins mechanistic and
interventional studies of brain aging and neurodegenerative diseases, especially dementia …

Parkinson's disease (PD) is a neurodegenerative disease, which is associated with
mitochondrial dysfunction and abnormal protein accumulation. No treatment can stop or …

Significance: Once considered to be mere by-products of metabolism, reactive oxygen,
nitrogen and sulfur species are now recognized to play important roles in diverse cellular …

Brains from persons with Alzheimer disease (AD) and its earlier stage, amnestic mild
cognitive impairment (MCI), exhibit high levels of oxidative damage, including that to …

Background There is increasing interest in therapeutic ketosis as a potential therapy for
neurodegenerative disorders–in particular, mild cognitive impairment (MCI), Alzheimer's …

Cisplatin resistance is one of the main causes of treatment failure and death in head and
neck squamous cell carcinoma (HNSCC). A more comprehensive understanding of the …

Mitochondria, the 'powerhouse'of eukaryotic cells, play a key role in cellular homeostasis.
However, defective mitochondria increase mitochondrial ROS (mtROS) production and cell …

Human performance, endurance, and resilience have biological limits that are genetically
and epigenetically predetermined but perhaps not yet optimized. There are few systematic …

Diminished cognitive and mood function are among the most conspicuous symptoms of Gulf
War Illness (GWI). Our previous studies in a rat model of GWI have demonstrated that …

Energy deficiency profoundly disrupts normal endocrinology, metabolism, and physiology,
resulting in an orchestrated response for energy preservation. As such, despite energy …