Stem cell factor (SCF) is a dimeric molecule that exerts its biological functions by binding to
and activating the receptor tyrosine kinase c-Kit. Activation of c-Kit leads to its …

Receptor tyrosine kinases (RTKs) are single-span transmembrane receptors in which
relatively conserved intracellular kinase domains are coupled to divergent extracellular …

В монографии приведены сведения по роли цитокинов в регуляции физиологических
процессов, защитных реакций организма и в патогенезе иммунопатологических …

Summary Stem Cell Factor (SCF) initiates its multiple cellular responses by binding to the
ectodomain of KIT, resulting in tyrosine kinase activation. We describe the crystal structure of …

Signaling by stem cell factor and Kit, its receptor, play important roles in gametogenesis,
hematopoiesis, mast cell development and function, and melanogenesis. Moreover, human …

The receptor tyrosine kinase c-Kit is expressed in hematopoietic stem and progenitor cells
and in several non-hematopoietic tissues. In the hematopoietic system, c-Kit is critical for …

Recent studies have done much to reveal the biological and genetic underpinnings of
gastrointestinal stromal tumors (GISTs). Constitutive activation of the KIT receptor tyrosine …

Kit is a receptor tyrosine kinase (RTK) that binds stem cell factor. This receptor ligand
combination is important for normal hematopoiesis, as well as pigmentation, gut function …

Stem cell factor (SCF), the ligand of the c-Kit receptor, is expressed by various structural and
inflammatory cells in the airways. Binding of SCF to c-Kit leads to activation of multiple …

The receptors for platelet-derived growth factor (PDGF) and stem cell factor (SCF) are
members of the type III class of PTK receptors, which are characterized by five Ig-like …