Food applications and potential health benefits of pomegranate and its derivatives

P Kandylis, E Kokkinomagoulos - Foods, 2020 - mdpi.com
Pomegranate (Punica granatum L.) is an ancient fruit that is particularly cultivated in west
Asia, though it is also cultivated in the Mediterranean region and other parts of the world …

Chronic stress and oxidative stress as common factors of the pathogenesis of depression and Alzheimer's disease: The role of antioxidants in prevention and …

G Juszczyk, J Mikulska, K Kasperek, D Pietrzak… - Antioxidants, 2021 - mdpi.com
There is a growing body of scientific research showing the link between depression and
dementia in Alzheimer's disease (AD). The chronic stress contributes to the formation of …

A review of dietary phytochemicals and their relation to oxidative stress and human diseases

R Guan, Q Van Le, H Yang, D Zhang, H Gu, Y Yang… - Chemosphere, 2021 - Elsevier
Phytochemicals refer to active substances in plant-based diets. Phytochemicals found in for
example fruits, vegetables, grains and seed oils are considered relatively safe for …

Urolithin A promotes mitophagy and suppresses NLRP3 inflammasome activation in lipopolysaccharide-induced BV2 microglial cells and MPTP-induced Parkinson's …

J Qiu, Y Chen, J Zhuo, L Zhang, J Liu, B Wang… - …, 2022 - Elsevier
Microglia-mediated neuroinflammation and mitochondrial dysfunction play critical role in the
pathogenic process of Parkinson's disease (PD). Mitophagy plays central role in …

Ellagic acid and intestinal microflora metabolite urolithin A: A review on its sources, metabolic distribution, health benefits, and biotransformation

M Zhang, S Cui, B Mao, Q Zhang, J Zhao… - Critical reviews in …, 2023 - Taylor & Francis
Foods rich in ellagic tannins are first hydrolyzed into ellagic acid in the stomach and small
intestine, and then converted into urolithins with high bioavailability by the intestinal flora …

The impact of ellagitannins and their metabolites through gut microbiome on the gut health and brain wellness within the gut–brain axis

R Banc, ME Rusu, L Filip, DS Popa - Foods, 2023 - mdpi.com
Ellagitannins (ETs) are a large group of bioactive compounds found in plant-source foods,
such as pomegranates, berries, and nuts. The consumption of ETs has often been …

Natural antioxidant compounds as potential pharmaceutical tools against neurodegenerative diseases

A Marino, M Battaglini, N Moles, G Ciofani - ACS omega, 2022 - ACS Publications
Natural antioxidants are a very large diversified family of molecules classified by activity
(enzymatic or nonenzymatic), chemical-physical properties (eg, hydrophilic or lipophilic) …

[HTML][HTML] Ellagitannins, urolithins, and neuroprotection: Human evidence and the possible link to the gut microbiota

R García-Villalba, FA Tomás-Barberán… - Molecular Aspects of …, 2023 - Elsevier
Ellagitannins (ETs) and ellagic acid (EA) are dietary polyphenols poorly absorbed but
extensively metabolized by the human gut microbiota to produce different urolithins (Uros) …

Urolithin A suppresses high glucose-induced neuronal amyloidogenesis by modulating TGM2-dependent ER-mitochondria contacts and calcium homeostasis

HJ Lee, YH Jung, GE Choi, JS Kim, CW Chae… - Cell Death & …, 2021 - nature.com
Hyperglycemia in diabetes mellitus (DM) patients is a causative factor for amyloidogenesis
and induces neuropathological changes, such as impaired neuronal integrity …

Pomegranate variety and pomegranate plant part, relevance from bioactive point of view: A review

P Melgarejo-Sánchez, D Núñez-Gómez… - Bioresources and …, 2021 - Springer
Pomegranate (Punica granatum L.) belongs to the Punicaceae plant family. It is an important
fruit due to its nutritional and medicinal properties. Pomegranates are widely distributed …