Epidemiology and prevention of prostate cancer
Abstract Context Worldwide, prostate cancer (PCa) represents the second most common
solid tumor in men. Objective To assess the geographical distribution of PCa …
solid tumor in men. Objective To assess the geographical distribution of PCa …
Deconstructing, addressing, and eliminating racial and ethnic inequities in prostate cancer care
YA Nyame, MR Cooperberg, MG Cumberbatch… - European urology, 2022 - Elsevier
Abstract Context Men of African ancestry have demonstrated markedly higher rates of
prostate cancer mortality than men of other races and ethnicities around the world. In fact …
prostate cancer mortality than men of other races and ethnicities around the world. In fact …
Cancer statistics for African American/black people 2022
Abstract African American/Black individuals have a disproportionate cancer burden,
including the highest mortality and the lowest survival of any racial/ethnic group for most …
including the highest mortality and the lowest survival of any racial/ethnic group for most …
Genome-wide analyses of 200,453 individuals yield new insights into the causes and consequences of clonal hematopoiesis
SP Kar, PM Quiros, M Gu, T Jiang, J Mitchell… - Nature Genetics, 2022 - nature.com
Clonal hematopoiesis (CH), the clonal expansion of a blood stem cell and its progeny driven
by somatic driver mutations, affects over a third of people, yet remains poorly understood …
by somatic driver mutations, affects over a third of people, yet remains poorly understood …
Development of a clinical polygenic risk score assay and reporting workflow
Implementation of polygenic risk scores (PRS) may improve disease prevention and
management but poses several challenges: the construction of clinically valid assays …
management but poses several challenges: the construction of clinically valid assays …
Cross-ancestry genome-wide meta-analysis of 61,047 cases and 947,237 controls identifies new susceptibility loci contributing to lung cancer
To identify new susceptibility loci to lung cancer among diverse populations, we performed
cross-ancestry genome-wide association studies in European, East Asian and African …
cross-ancestry genome-wide association studies in European, East Asian and African …
[PDF][PDF] Genome-wide risk prediction of common diseases across ancestries in one million people
Polygenic risk scores (PRS) measure genetic disease susceptibility by combining risk effects
across the genome. For coronary artery disease (CAD), type 2 diabetes (T2D), and breast …
across the genome. For coronary artery disease (CAD), type 2 diabetes (T2D), and breast …
Characterizing prostate cancer risk through multi-ancestry genome-wide discovery of 187 novel risk variants
The transferability and clinical value of genetic risk scores (GRSs) across populations
remain limited due to an imbalance in genetic studies across ancestrally diverse …
remain limited due to an imbalance in genetic studies across ancestrally diverse …
Polygenic scores in cancer
Since the publication of the first genome-wide association study for cancer in 2007,
thousands of common alleles that are associated with the risk of cancer have been …
thousands of common alleles that are associated with the risk of cancer have been …
[HTML][HTML] Disparities and trends in genitourinary cancer incidence and mortality in the USA
Background Previous studies have reported on incidence and mortality patterns for
individual genitourinary cancers in the USA. However, these studies addressed individual …
individual genitourinary cancers in the USA. However, these studies addressed individual …