The regulation of antibody production is linked to the generation and maintenance of
plasmablasts and plasma cells from their B cell precursors. Plasmablasts are the rapidly …

Plasmablastic lymphoma (PBL) is an aggressive lymphoma commonly associated with HIV
infection. However, PBL can also be seen in patients with other immunodeficiencies as well …

There is little insight into or agreement about the signals that control differentiation of
memory B cells (MBCs) and long-lived plasma cells (LLPCs). By performing BrdU pulse …

Antibody production is an important feature of the vertebrate immune system. Antibodies
neutralize and clear pathogens, thereby protecting against infectious diseases. Such …

The longevity of plasma cells is dependent on their ability to access and reside in so-called
niches that are predominantly located in the bone marrow. Here, by employing a traceable …

Humoral immunity consists of pre-existing antibodies expressed by long-lived plasma cells
and rapidly reactive memory B cells (MBC). Recent studies of MBC development and …

T follicular regulatory (Tfr) cells are a subset of Foxp3+ regulatory T (Treg) cells that form in
response to immunization or infection, which localize to the germinal centre where they …

The COVID pandemic has refreshed and expanded recognition of the vital role that
sustained antibody (Ab) secretion plays in our immune defenses against microbes and of …

Germinal centers (GCs) are the sites where B cells undergo affinity maturation. The
regulation of cellular output from the GC is not well understood. Here, we show that from the …

T cells are known to migrate to B‐cell‐enriched follicles and germinal centers within
secondary lymphoid organs to provide help to B cells. Cognate T: B interactions that take …