Publisher Summary Although osteoporosis has long been considered a disease of women,
the earliest reports of the epidemiology of fractures associated with osteoporosis clearly …

OBJECTIVE To evaluate the literature associating the risk of fracture during antidepressant
therapy. DATA SOURCES Literature was identified via MEDLINE (1970–August 2008) using …

Hip fracture is the most common complication of osteoporosis, and its major contributor is
compromised femoral strength. This study aimed to develop practical machine learning …

Low-density lipoprotein receptor–related protein 5 (LRP5) was identified as a major
contributor to bone health when loss-offunction mutations in LRP5 were discovered to be …

Patients taking antidepressants, including Clomipramine (CLP), have an increased risk of
osteoporotic fracture. However, the effects of CLP on bone metabolism are unknown. Here …

With aging, the burden of osteoporotic fracture (OF) increases substantially, while China is
expected to carry the greatest part in the future. The risk of fracture varies greatly across …

Targeting osteoblast may be the means of effectively improving both bone quality and mass,
thus offering an intriguing alternative in the treatment of osteoporosis. Aside from injectable …

Background: Research findings regarding the association between tricyclic antidepressant
(TCA) treatment and the risk of fracture are not consistent; we aimed to assess whether …

Osteoporosis frequently remains underrecognized and undertreated in men. Most
osteoporosis-related fractures could be prevented if men at risk would be diagnosed …

Men and their physicians should be aware of the risk for osteoporosis and the gender
differences that exist within this disease. Further research is needed to continue to …