Clinical promise of next-generation complement therapeutics
The complement system plays a key role in pathogen immunosurveillance and tissue
homeostasis. However, subversion of its tight regulatory control can fuel a vicious cycle of …
homeostasis. However, subversion of its tight regulatory control can fuel a vicious cycle of …
HUS and atypical HUS
TS Jokiranta - Blood, The Journal of the American Society of …, 2017 - ashpublications.org
Hemolytic uremic syndrome (HUS) is a thrombotic microangiopathy characterized by
intravascular hemolysis, thrombocytopenia, and acute kidney failure. HUS is usually …
intravascular hemolysis, thrombocytopenia, and acute kidney failure. HUS is usually …
[HTML][HTML] Complement in secondary thrombotic microangiopathy
LMP Palma, M Sridharan, S Sethi - Kidney international reports, 2021 - Elsevier
Thrombotic microangiopathy (TMA) is a condition characterized by thrombocytopenia and
microangiopathic hemolytic anemia (MAHA) with varying degrees of organ damage in the …
microangiopathic hemolytic anemia (MAHA) with varying degrees of organ damage in the …
Eculizumab in secondary atypical haemolytic uraemic syndrome
T Cavero, C Rabasco, A López… - Nephrology Dialysis …, 2017 - academic.oup.com
Background. Complement dysregulation occurs in thrombotic microangiopathies (TMAs)
other than primary atypical haemolytic uraemic syndrome (aHUS). A few of these patients …
other than primary atypical haemolytic uraemic syndrome (aHUS). A few of these patients …
Microvascular thrombosis: experimental and clinical implications
MA Bray, SE Sartain, J Gollamudi, RE Rumbaut - Translational Research, 2020 - Elsevier
A significant amount of clinical and research interest in thrombosis is focused on large
vessels (eg, stroke, myocardial infarction, deep venous thrombosis, etc.); however …
vessels (eg, stroke, myocardial infarction, deep venous thrombosis, etc.); however …
COPD as an endothelial disorder: endothelial injury linking lesions in the lungs and other organs?(2017 Grover Conference Series)
Chronic obstructive pulmonary disease (COPD) is characterized by chronic expiratory
airflow obstruction that is not fully reversible. COPD patients develop varying degrees of …
airflow obstruction that is not fully reversible. COPD patients develop varying degrees of …
Complement C3-targeted therapy: replacing long-held assertions with evidence-based discovery
Complement dysregulation underlies several inflammatory disorders, and terminal
complement inhibition has thus far afforded significant clinical gains. Nonetheless, emerging …
complement inhibition has thus far afforded significant clinical gains. Nonetheless, emerging …
[HTML][HTML] Thrombotic microangiopathy associated with monoclonal gammopathy
Thrombotic microangiopathy (TMA) is a rare disease comprising of a diverse set of disorders
linked by a common histologic finding of endothelial injury. Monoclonal immunoglobulins …
linked by a common histologic finding of endothelial injury. Monoclonal immunoglobulins …
[HTML][HTML] Developments in anti-complement therapy; from disease to clinical trial
The complement system is well known for its role in innate immunity and in maintenance of
tissue homeostasis, providing a first line of defence against infection and playing a key role …
tissue homeostasis, providing a first line of defence against infection and playing a key role …
[HTML][HTML] Inherited kidney complement diseases
In the past 20 years, we have witnessed tremendous advances in our ability to diagnose and
treat genetic diseases of the kidney caused by complement dysregulation. Staggering …
treat genetic diseases of the kidney caused by complement dysregulation. Staggering …