HTLV-I, the etiological agent in adult T-cell leukemia, has also been strongly implicated in a
number of non-neoplastic T-cell-associated diseases. Here, Junji Yodoi and Takashi …

Abstract Naturally occurring CD25+ CD4+ regulatory T cells are engaged in the
maintenance of immunological self-tolerance and down-regulation of various immune …

HTLV‐I transformed T cells not only express a large number of interleukin‐2 receptors [IL‐
2R/p55 (Tac)], but also produce a factor named ATL‐derived factor (ADF) that augments the …

Interleukin 1 (IL-1) has been obtained from the Epstein-Barr virus-infected B-lymphoblastoid
cell line 3B6 and shown to be involved in autocrine growth of 3B6 B cells. Independently …

Publisher Summary Adult T-cell leukemia-derived factor (ADF) plays an important role in the
transforming properties of HTLV-I by interfering with the expression of the interleukin-2 …

Adult T‐cell leukemia‐derived factor (ADF), originally defined as an interleukin‐2 receptor
inducer, is a human thioredoxin homologue. ADF is detected in many malignant tissues and …

Sézary syndrome is a cutaneous T cell lymphoma characterized by infiltration of the skin by
CD4+ cells. These cells generally respond poorly to mitogens and T cell activators. We have …

The protein p27KIP1 belongs to a recently identified family of proteins termed cyclin-
dependent kinase inhibitors (CDKIs). These proteins play an important role in regulating cell …

Adult T cell leukemia/lymphoma (ATLL) is one of the peripheral T cell malignant neoplasms
strongly associated with human T cell leukemia virus type-I (HTLV-I). Although the viral …

Interleukin 2 (IL-2) receptor/Tac antigen is abnormally expressed on cells of patients with
adult T cell leukemia (ATL) caused by infection with human T lymphotropic virus type I …