Extracellular secretion of proteins is regarded as a major virulence mechanism in bacterial
infection. Proteins destined for the extracellular environment of gram-negative bacteria have …

Homologues of the protein constituents of the Klebsiella pneumoniae (Klebsiella oxytoca)
type II secreton (T2S), the Pseudomonas aeruginosa type IV pilus/fimbrium biogenesis …

The type II secretion system (T2SS) is a multi‐protein complex used by many bacteria to
move substrates across their cell membrane. Substrates released into the environment …

The type II secretion pathway or the main terminal branch of the general secretion pathway,
as it has also been referred to, is widely distributed among Proteobacteria, in which it is …

abstract Gram-negative bacteria use the type II secretion system to transport a large number
of secreted proteins from the periplasmic space into the extracellular environment. Many of …

The skin, the oral cavity, and the gastrointestinal tract of humans are colonized with bacteria.
Microbial entry into the blood or blood-circulated tissues is hindered by anatomical barriers …

The type II secretion system (T2SS) delivers toxins and a range of hydrolytic enzymes,
including proteases, lipases, and carbohydrate-active enzymes, to the cell surface or …

The highly conserved pilM/N/O/P/Q gene cluster is among the core set of genes required for
cell surface expression of type IV pili and associated twitching motility. With the exception of …

Motility and protein secretion are key processes contributing to bacterial virulence. A wealth
of phylogenetic, biochemical and structural evidence support the hypothesis that the widely …

Pseudomonas aeruginosa type IV pili (T4P) are virulence factors that promote infection of
cystic fibrosis and immunosuppressed patients. As the absence of T4P impairs colonization …