Immunosenescence is a process of immune dysfunction that occurs with age and includes
remodeling of lymphoid organs, leading to changes in the immune function of the elderly …

Objectives: Common origins for brain metastases (BMs) are melanoma, lung, breast, and
renal cell cancers. BMs account for a large share of morbidity and mortality caused by these …

OBJECTIVE Immunotherapy, particularly immune checkpoint inhibitors (ICIs), has
revolutionized the treatment of patients with many tumor histologies. Simultaneously …

In patients with bone metastases (BM), radiotherapy (RT) is used to alleviate symptoms,
reduce the risk of fracture, and improve quality of life (QoL). However, with the emergence of …

Background Stereotactic radiosurgery (SRS) has been increasingly applied for up to 10
brain metastases instead of whole brain radiation therapy (WBRT) to achieve local tumor …

Radiotherapy (RT) plays a diverse and essential role in the contemporary management of
non-Hodgkin lymphoma (NHL) and remains the single most powerful monotherapeutic …

The immune system uses various immune checkpoint axes to adjust responses, support
homeostasis, and deter self-reactivity and autoimmunity. Nevertheless, non-small-cell lung …

Despite considerable progress with our understanding of glioblastoma multiforme (GBM)
and the precise delivery of radiotherapy, the prognosis for GBM patients is still unfavorable …

The constantly increasing life expectancy is raising the issue of treating oncological older
patients, who were traditionally candidates to best supportive care or palliative treatments …

Old or very old oncological patients represent a heterogeneous and frail population due to
concomitant comorbidities. Whether radiotherapy alone or in combination with novel cancer …