The fields of application of functional proteomics are not limited to the study of protein–
protein interactions; they also extend to those involving protein complexes that bind DNA or …

Single-stranded DNA (ssDNA) binding proteins (SSBs) are critical in maintaining genome
stability by protecting the transient existence of ssDNA from damage during essential …

AS1411 aptamer can function as a recognition probe to detect the cell surface nucleolin
overexpressed in cancer cells, however, little is known about their binding process. This …

Understanding gene expression will require understanding where regulatory factors bind
genomic DNA. The frequently used sequence-based motifs of protein-DNA binding are not …

Hydrogen bonds play important roles in protein folding and protein–ligand interactions,
particularly in specific protein–DNA recognition. However, the distributions of hydrogen …

DNA is the primary genetic material that is highly compatible with biological system, and its
intrinsic property of complementary base pairing can be programmed for analysis. However …

BACKGROUND: Hypertrophic cardiomyopathy (HCM) is the most prevalent monogenic
heart disorder. However, the pathogenesis of HCM, especially its nongenetic mechanisms …

ZBTB7A belongs to a small family of transcription factors having three members in humans
(7A, 7B, and 7C). They share a BTB/POZ protein interaction domain at the amino end and a …

Protein− nucleic acid interactions, including the interac-tions of proteins with DNA, RNA, and
DNA/RNA hybrid, often confer important biological consequences to targeted nucleic acids …

Biomacromolecules with complex structures, are important components of living things. Due
to the sensitivity of biomacromolecules to various influencing factors like temperature …