Small vulnerable newborns—big potential for impact

P Ashorn, U Ashorn, Y Muthiani, S Aboubaker, S Askari… - The Lancet, 2023 - thelancet.com
Despite major achievements in child survival, the burden of neonatal mortality has remained
high and even increased in some countries since 1990. Currently, most neonatal deaths are …

Diagnosis of neonatal sepsis: the past, present and future

IH Celik, M Hanna, FE Canpolat, M Pammi - Pediatric research, 2022 - nature.com
Sepsis remains a significant cause of neonatal mortality and morbidity, especially in low-and
middle-income countries. Neonatal sepsis presents with nonspecific signs and symptoms …

Epidemiology and immune pathogenesis of viral sepsis

GL Lin, JP McGinley, SB Drysdale… - Frontiers in …, 2018 - frontiersin.org
Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to
infection. Sepsis can be caused by a broad range of pathogens; however, bacterial …

Neonatal sepsis: a review of pathophysiology and current management strategies

MA Glaser, LM Hughes, A Jnah… - Advances in neonatal …, 2021 - journals.lww.com
Background: Early-onset sepsis, occurring within 72 hours of birth, and late-onset sepsis,
occurring after this time period, present serious risks for neonates. While culture-based …

Neonatal sepsis of early onset, and hospital-acquired and community-acquired late onset: a prospective population-based cohort study

E Giannoni, PKA Agyeman, M Stocker… - The Journal of …, 2018 - Elsevier
Objective To assess the epidemiology of blood culture-proven early-(EOS) and late-onset
neonatal sepsis (LOS). Study design All newborn infants admitted to tertiary care neonatal …

Antibiotic resistance genes in the gut microbiota of mothers and linked neonates with or without sepsis from low-and middle-income countries

MJ Carvalho, K Sands, K Thomson, E Portal… - Nature …, 2022 - nature.com
Early development of the microbiome has been shown to affect general health and physical
development of the infant and, although some studies have been undertaken in high-income …

Risk factors of neonatal sepsis in India: A systematic review and meta-analysis

S Murthy, MA Godinho, V Guddattu, LES Lewis… - PloS one, 2019 - journals.plos.org
Background The incidence of neonatal sepsis in India is the highest in the world. Evidence
regarding its risk factors can guide clinical practice and prevention strategies. Objective To …

Culture-negative early-onset neonatal sepsis—at the crossroad between efficient sepsis care and antimicrobial stewardship

C Klingenberg, RF Kornelisse, G Buonocore… - Frontiers in …, 2018 - frontiersin.org
Sepsis is a leading cause of mortality and morbidity in neonates. Presenting clinical
symptoms are unspecific. Sensitivity and positive predictive value of biomarkers at onset of …

[PDF][PDF] Neonatal sepsis

IO Odabasi, A Bulbul - Şişli Etfal Hastanesi Tip Bülteni, 2020 - jag.journalagent.com
Neonatal sepsis is associated with severe morbidity and mortality in the neonatal period.
Clinical manifestations range from subclinical infection to severe local or systemic infection …

A neonatal sequential organ failure assessment score predicts mortality to late-onset sepsis in preterm very low birth weight infants

JL Wynn, RA Polin - Pediatric research, 2020 - nature.com
Background An operational definition of organ dysfunction applicable to neonates that
predicts mortality in the setting of infection is lacking. We determined the utility of an …