The adenosine modulation system mostly operates through inhibitory A1 (A1R) and
facilitatory A2A receptors (A2AR) in the brain. The activity‐dependent release of adenosine …

This review discusses the evidence supporting a role for ATP signaling (operated by P 2 X
and P 2 Y receptors) and adenosine signaling (mainly operated by A 1 and A 2A receptors) …

Synaptic plasticity in the autoassociative network of recurrent connections among
hippocampal CA3 pyramidal cells is thought to enable the storage of episodic memory …

Synaptic dysfunction plays a central role in Alzheimer's disease (AD), since it drives the
cognitive decline. An association between a polymorphism of the adenosine A2A receptor …

Major depressive disorder ranks as a major burden of disease worldwide, yet the current
antidepressant medications are limited by frequent non-responsiveness and significant side …

While neuronal loss has long been considered as the main contributor to age-related
cognitive decline, these alterations are currently attributed to gradual synaptic dysfunction …

Abnormal accumulation of aggregated α-synuclein (aSyn) is a hallmark of sporadic and
familial Parkinson's disease (PD) and related synucleinopathies. Recent studies suggest a …

Here we demonstrate for the first time that cannabidiol (CBD) acts to protect synaptic
plasticity in an in vitro model of Alzheimer's disease (AD). The non-psycho active component …

Abstract Adenosine A2A receptor (A2AR) activation modulates several brain processes,
ranging from neuronal maturation to synaptic plasticity. Most of these actions occur through …

In the present review, we stress the importance of the purine nucleosides, adenosine and
guanosine, in protecting the nervous system, both centrally and peripherally, via activation of …