Cellular senescence is a program activated by normal cells in response to various types of
stress. These include telomere uncapping, DNA damage, oxidative stress, oncogene activity …

Base excision repair (BER) is a frontline repair system that is responsible for maintaining
genome integrity and thus preventing premature aging, cancer and many other human …

Oxidative DNA damage constitutes a major threat to genetic integrity, and has thus been
implicated in the pathogenesis of a wide variety of diseases, including cancer and …

Mammalian cells that sustain oncogenic insults can invoke defensive programmes that
either halt their division or trigger their apoptosis, but these countermeasures must be finely …

The process of malignant transformation universally entails genetic damage and oncogenic
signaling, two stresses that are signaled to p53 through different genetic pathways. Based …

oxo-7, 8-dihydro-2′-deoxyguanosine (8-oxodG), a major product of DNA oxidation, is a pre-
mutagenic lesion which is prone to mispair, if left unrepaired, with 2′-deoxyadenosine …

Radiotherapy is a major cancer treatment option but dose-limiting side effects such as late-
onset fibrosis in the irradiated tissue severely impair quality of life in cancer survivors. Efforts …

Senescence is defined as an irreversible growth arrest that is characterised by a changed
morphology, gene expression pattern and chromatin structure as well as an activated DNA …

Background In individual living cells p53 has been found to be expressed in a series of
discrete pulses after DNA damage. Its negative regulator Mdm2 also demonstrates …

The p14 alternate reading frame (ARF) tumor suppressor plays a central role in cancer by
binding to mdm2 (Hdm2 in humans) and enhancing p53-mediated apoptosis following DNA …