The signals and pathways activating cellular senescence
I Ben-Porath, RA Weinberg - The international journal of biochemistry & …, 2005 - Elsevier
Cellular senescence is a program activated by normal cells in response to various types of
stress. These include telomere uncapping, DNA damage, oxidative stress, oncogene activity …
stress. These include telomere uncapping, DNA damage, oxidative stress, oncogene activity …
Mammalian base excision repair: the forgotten archangel
GL Dianov, U Hübscher - Nucleic acids research, 2013 - academic.oup.com
Base excision repair (BER) is a frontline repair system that is responsible for maintaining
genome integrity and thus preventing premature aging, cancer and many other human …
genome integrity and thus preventing premature aging, cancer and many other human …
[HTML][HTML] Not breathing is not an option: How to deal with oxidative DNA damage
E Markkanen - DNA repair, 2017 - Elsevier
Oxidative DNA damage constitutes a major threat to genetic integrity, and has thus been
implicated in the pathogenesis of a wide variety of diseases, including cancer and …
implicated in the pathogenesis of a wide variety of diseases, including cancer and …
Divorcing ARF and p53: an unsettled case
CJ Sherr - Nature Reviews Cancer, 2006 - nature.com
Mammalian cells that sustain oncogenic insults can invoke defensive programmes that
either halt their division or trigger their apoptosis, but these countermeasures must be finely …
either halt their division or trigger their apoptosis, but these countermeasures must be finely …
p53: guardian of the genome and policeman of the oncogenes
A Efeyan, M Serrano - Cell cycle, 2007 - Taylor & Francis
The process of malignant transformation universally entails genetic damage and oncogenic
signaling, two stresses that are signaled to p53 through different genetic pathways. Based …
signaling, two stresses that are signaled to p53 through different genetic pathways. Based …
[HTML][HTML] Towards a comprehensive view of 8-oxo-7, 8-dihydro-2'-deoxyguanosine: Highlighting the intertwined roles of DNA damage and epigenetics in genomic …
oxo-7, 8-dihydro-2′-deoxyguanosine (8-oxodG), a major product of DNA oxidation, is a pre-
mutagenic lesion which is prone to mispair, if left unrepaired, with 2′-deoxyadenosine …
mutagenic lesion which is prone to mispair, if left unrepaired, with 2′-deoxyadenosine …
Epigenetics in radiation-induced fibrosis
Radiotherapy is a major cancer treatment option but dose-limiting side effects such as late-
onset fibrosis in the irradiated tissue severely impair quality of life in cancer survivors. Efforts …
onset fibrosis in the irradiated tissue severely impair quality of life in cancer survivors. Efforts …
Cellular senescence in the development and treatment of cancer
G Saretzki - Current pharmaceutical design, 2010 - ingentaconnect.com
Senescence is defined as an irreversible growth arrest that is characterised by a changed
morphology, gene expression pattern and chromatin structure as well as an activated DNA …
morphology, gene expression pattern and chromatin structure as well as an activated DNA …
[HTML][HTML] Explaining oscillations and variability in the p53-Mdm2 system
CJ Proctor, DA Gray - BMC systems biology, 2008 - Springer
Background In individual living cells p53 has been found to be expressed in a series of
discrete pulses after DNA damage. Its negative regulator Mdm2 also demonstrates …
discrete pulses after DNA damage. Its negative regulator Mdm2 also demonstrates …
DNA damage disrupts the p14ARF-B23 (nucleophosmin) interaction and triggers a transient subnuclear redistribution of p14ARF
C Lee, BA Smith, K Bandyopadhyay, RA Gjerset - Cancer research, 2005 - AACR
The p14 alternate reading frame (ARF) tumor suppressor plays a central role in cancer by
binding to mdm2 (Hdm2 in humans) and enhancing p53-mediated apoptosis following DNA …
binding to mdm2 (Hdm2 in humans) and enhancing p53-mediated apoptosis following DNA …