Simple Summary The bone marrow (BM) microenvironment plays a crucial role in
pathogenesis of multiple myeloma (MM), and delineation of the intracellular signaling …

Multiple myeloma (MM) is a plasma-cell malignancy which remains incurable despite the
recent emergence of multiple novel agents. Importantly, recent genetic and molecular …

The insulin-like growth factor 1 receptor (IGF-1R) governs several signaling pathways for
cell proliferation, survival, and anti-apoptosis. Thus, targeting IGF-1R appears as a …

Multiple myeloma (MM), a cancer of terminally differentiated plasma cells, is the second
most common hematological malignancy. The disease is characterized by the accumulation …

Background Multiple myeloma (MM) remains an incurable cancer despite advances in
therapy. Therefore, the search for new targets is still essential to uncover potential treatment …

Side population (SP) cells are an enriched source of cancer-initiating cells with stemness
characteristics, generated by increased ABC transporter activity, which has served as a …

Deregulation and activation of the phosphoinositide 3-kinase (PI3K)/Akt/mammalian (or
mechanistic) target of rapamycin (mTOR) pathway have a major role in proliferation and cell …

Multiple Myeloma (MM) is a malignant plasma cell disorder with an unmet medical need, in
particular for relapsed and refractory patients. Molecules within deregulated signaling …

Abstract The PI3K/Akt pathway plays a crucial role in the pathogenesis of multiple myeloma
(MM) in the bone marrow (BM) milieu. However, efficacy of selective and potent Akt …

The transformation of myelodysplastic syndrome (MDS) into acute myeloid leukemia (AML)
poses a significant clinical challenge. The trimethylation of H3 on lysine 27 (H3K27me3) …