Correlation and association analyses in microbiome study integrating multiomics in health and disease
Y Xia - Progress in molecular biology and translational …, 2020 - Elsevier
Correlation and association analyses are one of the most widely used statistical methods in
research fields, including microbiome and integrative multiomics studies. Correlation and …
research fields, including microbiome and integrative multiomics studies. Correlation and …
Multiple testing corrections, nonparametric methods, and random field theory
TE Nichols - Neuroimage, 2012 - Elsevier
I provide a selective review of the literature on the multiple testing problem in fMRI. By
drawing connections with the older modalities, PET in particular, and how software …
drawing connections with the older modalities, PET in particular, and how software …
Topographic organization of the human subcortex unveiled with functional connectivity gradients
Brain atlases are fundamental to understanding the topographic organization of the human
brain, yet many contemporary human atlases cover only the cerebral cortex, leaving the …
brain, yet many contemporary human atlases cover only the cerebral cortex, leaving the …
Targeting T cell checkpoints 41BB and LAG3 and myeloid cell CXCR1/CXCR2 results in antitumor immunity and durable response in pancreatic cancer
Pancreatic ductal adenocarcinoma (PDAC) is considered non-immunogenic, with trials
showing its recalcitrance to PD1 and CTLA4 immune checkpoint therapies (ICTs). Here, we …
showing its recalcitrance to PD1 and CTLA4 immune checkpoint therapies (ICTs). Here, we …
Toward a realistic model of speech processing in the brain with self-supervised learning
Several deep neural networks have recently been shown to generate activations similar to
those of the brain in response to the same input. These algorithms, however, remain largely …
those of the brain in response to the same input. These algorithms, however, remain largely …
Comparison of 2D and 3D cell culture models for cell growth, gene expression and drug resistance
JC Fontoura, C Viezzer, FG Dos Santos… - Materials Science and …, 2020 - Elsevier
In vitro drug screening is widely used in the development of new drugs, because they
constitute a cost-effective approach to select compounds with more potential for therapy …
constitute a cost-effective approach to select compounds with more potential for therapy …
Panning for gold:'model-X'knockoffs for high dimensional controlled variable selection
Many contemporary large-scale applications involve building interpretable models linking a
large set of potential covariates to a response in a non-linear fashion, such as when the …
large set of potential covariates to a response in a non-linear fashion, such as when the …
A practical guide to methods controlling false discoveries in computational biology
Background In high-throughput studies, hundreds to millions of hypotheses are typically
tested. Statistical methods that control the false discovery rate (FDR) have emerged as …
tested. Statistical methods that control the false discovery rate (FDR) have emerged as …
Nontemplated nucleotide additions distinguish the small RNA composition in cells from exosomes
Functional biomolecules, including small noncoding RNAs (ncRNAs), are released and
transmitted between mammalian cells via extracellular vesicles (EVs), including endosome …
transmitted between mammalian cells via extracellular vesicles (EVs), including endosome …
Gut microbes impact stroke severity via the trimethylamine N-oxide pathway
Clinical studies have demonstrated associations between circulating levels of the gut-
microbiota-derived metabolite trimethylamine-N-oxide (TMAO) and stroke incident risk …
microbiota-derived metabolite trimethylamine-N-oxide (TMAO) and stroke incident risk …