Application of culturomics in fungal isolation from mangrove sediments
Background Fungi play a crucial role in ecosystems, and they have been widely considered
a promising source for natural compounds that are crucial for drug discovery. Fungi have a …
a promising source for natural compounds that are crucial for drug discovery. Fungi have a …
Higher criticism for large-scale inference, especially for rare and weak effects
In modern high-throughput data analysis, researchers perform a large number of statistical
tests, expecting to find perhaps a small fraction of significant effects against a predominantly …
tests, expecting to find perhaps a small fraction of significant effects against a predominantly …
Expert-augmented computational drug repurposing identified baricitinib as a treatment for COVID-19
DP Smith, O Oechsle, MJ Rawling, E Savory… - Frontiers in …, 2021 - frontiersin.org
The onset of the 2019 Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
pandemic necessitated the identification of approved drugs to treat the disease, before the …
pandemic necessitated the identification of approved drugs to treat the disease, before the …
Small molecule inhibition of gut microbial choline trimethylamine lyase activity alters host cholesterol and bile acid metabolism
P Pathak, RN Helsley, AL Brown… - American Journal …, 2020 - journals.physiology.org
The gut microbe-derived metabolite trimethylamine-N-oxide (TMAO) has recently been
linked to cardiovascular disease (CVD) pathogenesis, prompting the development of …
linked to cardiovascular disease (CVD) pathogenesis, prompting the development of …
C-NODDI: a constrained NODDI model for axonal density and orientation determinations in cerebral white matter
Purpose Neurite orientation dispersion and density imaging (NODDI) provides measures of
neurite density and dispersion through computation of the neurite density index (NDI) and …
neurite density and dispersion through computation of the neurite density index (NDI) and …
Discriminating cognitive status in Parkinson's disease through functional connectomics and machine learning
There is growing interest in the potential of neuroimaging to help develop non-invasive
biomarkers in neurodegenerative diseases. In this study, connection-wise patterns of …
biomarkers in neurodegenerative diseases. In this study, connection-wise patterns of …
[HTML][HTML] Mindfulness-based emotional eating awareness training: taking the emotional out of eating
P Lattimore - Eating and Weight Disorders-Studies on Anorexia …, 2020 - Springer
Purpose Emotional eating is important to study and address because it predicts poor
outcome in weight loss interventions. Interventions have only touched the surface in terms of …
outcome in weight loss interventions. Interventions have only touched the surface in terms of …
Comparative optimization of combinatorial CRISPR screens
Combinatorial CRISPR technologies have emerged as a transformative approach to
systematically probe genetic interactions and dependencies of redundant gene pairs …
systematically probe genetic interactions and dependencies of redundant gene pairs …
Adult brain aging investigated using BMC-mcDESPOT–based myelin water fraction imaging
The relationship between regional brain myelination and aging has been the subject of
intense study, with magnetic resonance imaging perhaps the most effective modality for …
intense study, with magnetic resonance imaging perhaps the most effective modality for …
[HTML][HTML] Sex and age-related differences in cerebral blood flow investigated using pseudo-continuous arterial spin labeling magnetic resonance imaging
JSR Alisch, N Khattar, RW Kim, LE Cortina… - Aging (Albany …, 2021 - ncbi.nlm.nih.gov
Adequate cerebral blood flow (CBF) is essential to a healthy central nervous system (CNS).
Previous work suggests that CBF differs between men and women, and declines with age …
Previous work suggests that CBF differs between men and women, and declines with age …