Cell-based immunotherapy for the treatment of hematologic malignancies, such as leukemia
and lymphoma, has seen much success and played an increasingly important role in clinical …

To gain a better understanding of intracellular processing of nanomedicines, we employed
quantitative live-cell fluorescence colocalization microscopy to study endosomal trafficking …

Aim: To develop a robust assay to evaluate and compare the intravitreal mobility of
nanoparticles in the intact vitreous body. Materials & methods: Excised bovine eyes were …

Background: Efficient and controlled internalization of NPs into the cells depends on their
physicochemical properties and dynamics of the plasma membrane. NPs-cell interaction is a …

The implementation of efficient strategies for cellular delivery is the most significant hurdle in
the development of oligonucleotide and protein-based nanomedicines. Unlike small …

Cancer development and progression of cancer are closely associated with the activation of
oncogenes and loss of tumor suppressor genes. Nucleic acid drugs (eg, siRNA, mRNA, and …

Despite the enormous therapeutic potential of siRNAs, their delivery is still problematic due
to unfavorable biodistribution profiles and poor intracellular bioavailability. Calcium …

Gene therapy is an efficient and promising approach to treat malignant tumors. However,
protecting the nucleic acid from degradation in vivo and efficient delivering it into tumor cells …

Lipoplexes and polyplexes, that is, assemblies of cationic lipids and polymers with nucleic
acids, respectively, are popular nanocarriers for delivery of genes or siRNA into cells for …

Recently, synthetic gene carriers have been intensively developed owing to their promising
application in gene therapy and considered as a suitable alternative to viral vectors because …