Both aging and cancer are characterized by a series of partially overlapping" hallmarks" that
we subject here to a meta-analysis. Several hallmarks of aging (ie, genomic instability …

Cellular senescence is a hallmark of aging defined by stable exit from the cell cycle in
response to cellular damage and stress. Senescent cells (SnCs) can develop a …

Heart regenerative medicine has been gradually evolving from a view of the heart as a
nonregenerative organ with terminally differentiated cardiac muscle cells. Understanding the …

During the progression of type 1 diabetes (T1D), β cells are exposed to significant stress
and, therefore, require adaptive responses to survive. The adaptive mechanisms that can …

The accumulation of senescent cells is recognised as a driver of tissue and organismal
ageing. One of the gold‐standard hallmarks of a senescent cell is an increase in lysosomal …

Originally identified as an outcome of continuous culture of primary cells, cellular
senescence has moved beyond the culture dish and is now a bona fide driver of aging and …

Idiopathic pulmonary fibrosis (IPF) is an irreversible and fatal lung disease that is primarily
found in the elderly population, and several studies have demonstrated that aging is the …

Cellular senescence is a complex process involving a close-to-irreversible arrest of the cell
cycle, the acquisition of the senescence-associated secretory phenotype (SASP), as well as …

Cigarette smoke (CS) leads to increased oxidative stress, inflammation, and exaggerated
senescence, which are involved in the pathogenesis of chronic obstructive pulmonary …

Brain aging is a recognized risk factor for neurodegenerative diseases like Alzheimer's
disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS, Lou Gehrig's …