Among the long list of age-related complications, Alzheimer's disease (AD) has the most
dreadful impact on the quality of life due to its devastating effects on memory and cognitive …

Alzheimer's disease (AD) is a severe, chronic and progressive neurodegenerative disease
associated with memory and cognition impairment ultimately leading to death. It is the …

Mechanistic/mammalian target of rapamycin (mTOR) belongs to the phosphatidylinositol
kinase-related kinase (PIKK) family. mTOR signaling is required for the commencement of …

Abstract Background Nuclear acetyl-CoA pools govern histone acetylation that controls
synaptic plasticity and contributes to cognitive deterioration in patients with Alzheimer's …

Alzheimer's disease (AD) is characterized by the formation of intracellular aggregate
composed of heavily phosphorylated tau protein and extracellular deposit of amyloid-β (Aβ) …

A robust preclinical disease model is a primary requirement to understand the underlying
mechanisms, signaling pathways, and drug screening for human diseases. Although various …

In recent years, a significant progress was made in understanding molecular mechanisms of
long-term memory. Long-term memory formation requires strengthening of neuronal …

The genus Tripterygium belongs to the family Celastraceae, and contains three species, ie
Tripterygium wilfordii Hook. F, Tripterygium hypoglaucum (Levl.) Hutch. and Tripterygium …

Abstract Alzheimer's disease (AD), the most common neurodegenerative disease
worldwide, is caused by loss of neurons and synapses in central nervous system. Several …

Background Alzheimer's disease (AD) is a neuropathology strongly associated with the
activation of inflammatory pathways. Accordingly, inflammation resulting from obesity …