[HTML][HTML] A white paper on a neurodevelopmental framework for drug discovery in autism and other neurodevelopmental disorders

CM Diaz-Caneja, MW State, RJ Hagerman… - European …, 2021 - Elsevier
In the last decade there has been a revolution in terms of genetic findings in
neurodevelopmental disorders (NDDs), with many discoveries critical for understanding …

A tribute to Leif Hertz: The historical context of his pioneering studies of the roles of astrocytes in brain energy metabolism, neurotransmission, cognitive functions, and …

GA Dienel, A Schousboe, MC McKenna… - Journal of …, 2024 - Wiley Online Library
Abstract Leif Hertz, MD, D. Sc.(honōris causā)(1930–2018), was one of the original and
noteworthy participants in the International Conference on Brain Energy Metabolism …

Synaesthesia and autism: Different developmental outcomes from overlapping mechanisms?

TM Van Leeuwen, J Neufeld, J Hughes… - Cognitive …, 2020 - Taylor & Francis
Synaesthesia, a mixing of the senses, is more common in individuals with autism. Here, we
review the evidence for the association between synaesthesia and autism with regard to …

Associations between sensory processing and electrophysiological and neurochemical measures in children with ASD: an EEG-MRS study

S Pierce, G Kadlaskar, DA Edmondson… - Journal of …, 2021 - Springer
Background Autism spectrum disorder (ASD) is associated with hyper-and/or hypo-
sensitivity to sensory input. Spontaneous alpha power, which plays an important role in …

Dynamic functional connectivity alterations and their associated gene expression pattern in autism spectrum disorders

L Ma, T Yuan, W Li, L Guo, D Zhu, Z Wang… - Frontiers in …, 2022 - frontiersin.org
Autism spectrum disorders (ASDs) are a group of heterogeneous neurodevelopmental
disorders that are highly heritable and are associated with impaired dynamic functional …

Revisiting the excitation/inhibition imbalance hypothesis of ASD through a clinical lens

RG Port, LM Oberman… - The British journal of …, 2019 - academic.oup.com
Autism spectrum disorder (ASD) currently affects 1 in 59 children, although the aetiology of
this disorder remains unknown. Faced with multiple seemingly disparate and noncontiguous …

Transcranial direct current stimulation as an approach to mitigate neurodevelopmental disorders affecting excitation/inhibition balance: Focus on autism spectrum …

B Sousa, J Martins, M Castelo-Branco… - Journal of Clinical …, 2022 - mdpi.com
Transcranial direct current stimulation (tDCS) has been proposed as a promising therapy for
rehabilitation of neurodevelopmental disorders. In this review, we discuss studies on the …

Probiotics and prebiotics alleviate behavioral deficits, inflammatory response, and gut dysbiosis in prenatal VPA-induced rodent model of autism

E Adıgüzel, B Çiçek, G Ünal, MF Aydın… - Physiology & …, 2022 - Elsevier
Autism spectrum disorders are neuropsychiatric conditions characterized by social
interaction and communication disorders and repetitive stereotypical behaviors. These …

Predicting learning and achievement using GABA and glutamate concentrations in human development

G Zacharopoulos, F Sella, K Cohen Kadosh… - PLoS …, 2021 - journals.plos.org
Previous research has highlighted the role of glutamate and gamma-aminobutyric acid
(GABA) in learning and plasticity. What is currently unknown is how this knowledge …

Emerging evidence linking the gut microbiome to neurologic disorders

JA Griffiths, SK Mazmanian - Genome medicine, 2018 - Springer
Editorial summary The gut microbiome contributes to the development and function of the
immune, metabolic, and nervous systems. Furthermore, commensal bacteria modulate …