From bench to bedside: The mGluR5 system in people with and without Autism Spectrum Disorder and animal model systems
C Carey, N Singh, JT Dunn, T Sementa… - Translational …, 2022 - nature.com
The metabotropic glutamate receptor 5 (mGluR5) is a key regulator of excitatory (E)
glutamate and inhibitory (I) γ-amino butyric acid (GABA) signalling in the brain. Despite the …
glutamate and inhibitory (I) γ-amino butyric acid (GABA) signalling in the brain. Despite the …
Transcranial direct current stimulation as an approach to mitigate neurodevelopmental disorders affecting excitation/inhibition balance: Focus on autism spectrum …
B Sousa, J Martins, M Castelo-Branco… - Journal of Clinical …, 2022 - mdpi.com
Transcranial direct current stimulation (tDCS) has been proposed as a promising therapy for
rehabilitation of neurodevelopmental disorders. In this review, we discuss studies on the …
rehabilitation of neurodevelopmental disorders. In this review, we discuss studies on the …
[HTML][HTML] Bridging the translational gap: what can synaptopathies tell us about autism?
CJ Molloy, J Cooke, NJF Gatford… - Frontiers in Molecular …, 2023 - ncbi.nlm.nih.gov
Multiple molecular pathways and cellular processes have been implicated in the
neurobiology of autism and other neurodevelopmental conditions. There is a current focus …
neurobiology of autism and other neurodevelopmental conditions. There is a current focus …
Probiotics and prebiotics alleviate behavioral deficits, inflammatory response, and gut dysbiosis in prenatal VPA-induced rodent model of autism
Autism spectrum disorders are neuropsychiatric conditions characterized by social
interaction and communication disorders and repetitive stereotypical behaviors. These …
interaction and communication disorders and repetitive stereotypical behaviors. These …
The role of GABAergic neural circuits in the pathogenesis of autism spectrum disorder
J Di, J Li, B O'Hara, I Alberts, L Xiong… - International Journal of …, 2020 - Wiley Online Library
Autism spectrum disorder (ASD) comprises a heterogeneous range of neurodevelopmental
conditions represented by symptoms including, communication and language deficits …
conditions represented by symptoms including, communication and language deficits …
Emerging evidence linking the gut microbiome to neurologic disorders
JA Griffiths, SK Mazmanian - Genome medicine, 2018 - Springer
Editorial summary The gut microbiome contributes to the development and function of the
immune, metabolic, and nervous systems. Furthermore, commensal bacteria modulate …
immune, metabolic, and nervous systems. Furthermore, commensal bacteria modulate …
[HTML][HTML] Treatment effect of bumetanide in children with autism spectrum disorder: a systematic review and meta-analysis
T Wang, L Shan, C Miao, Z Xu, F Jia - Frontiers in Psychiatry, 2021 - frontiersin.org
Background: The therapeutic effect of bumetanide on autism spectrum disorder (ASD)
seems to be controversial. To obtain better evidence on the efficacy of bumetanide, a …
seems to be controversial. To obtain better evidence on the efficacy of bumetanide, a …
The effect of lead exposure on autism development
A Goel, M Aschner - International Journal of Molecular Sciences, 2021 - mdpi.com
Autism Spectrum Disorder (ASD) remains one of the most detrimental neurodevelopmental
conditions in society today. Common symptoms include diminished social and …
conditions in society today. Common symptoms include diminished social and …
Resolving the synaptic versus developmental dichotomy of autism risk genes
WE Heavner, SEP Smith - Trends in neurosciences, 2020 - cell.com
Genes that are mutated in Autism Spectrum Disorders (ASD) can be classified broadly as
either synaptic or developmental. But what if this is a false distinction? A recent spate of …
either synaptic or developmental. But what if this is a false distinction? A recent spate of …
Disruption of circadian rhythm and risk of autism spectrum disorder: role of immune-inflammatory, oxidative stress, metabolic and neurotransmitter pathways
Circadian rhythms in most living organisms are regulated by light and synchronized to an
endogenous biological clock. The circadian clock machinery is also critically involved in …
endogenous biological clock. The circadian clock machinery is also critically involved in …