From bench to bedside: The mGluR5 system in people with and without Autism Spectrum Disorder and animal model systems

C Carey, N Singh, JT Dunn, T Sementa… - Translational …, 2022 - nature.com
The metabotropic glutamate receptor 5 (mGluR5) is a key regulator of excitatory (E)
glutamate and inhibitory (I) γ-amino butyric acid (GABA) signalling in the brain. Despite the …

Transcranial direct current stimulation as an approach to mitigate neurodevelopmental disorders affecting excitation/inhibition balance: Focus on autism spectrum …

B Sousa, J Martins, M Castelo-Branco… - Journal of Clinical …, 2022 - mdpi.com
Transcranial direct current stimulation (tDCS) has been proposed as a promising therapy for
rehabilitation of neurodevelopmental disorders. In this review, we discuss studies on the …

[HTML][HTML] Bridging the translational gap: what can synaptopathies tell us about autism?

CJ Molloy, J Cooke, NJF Gatford… - Frontiers in Molecular …, 2023 - ncbi.nlm.nih.gov
Multiple molecular pathways and cellular processes have been implicated in the
neurobiology of autism and other neurodevelopmental conditions. There is a current focus …

Probiotics and prebiotics alleviate behavioral deficits, inflammatory response, and gut dysbiosis in prenatal VPA-induced rodent model of autism

E Adıgüzel, B Çiçek, G Ünal, MF Aydın… - Physiology & …, 2022 - Elsevier
Autism spectrum disorders are neuropsychiatric conditions characterized by social
interaction and communication disorders and repetitive stereotypical behaviors. These …

The role of GABAergic neural circuits in the pathogenesis of autism spectrum disorder

J Di, J Li, B O'Hara, I Alberts, L Xiong… - International Journal of …, 2020 - Wiley Online Library
Autism spectrum disorder (ASD) comprises a heterogeneous range of neurodevelopmental
conditions represented by symptoms including, communication and language deficits …

Emerging evidence linking the gut microbiome to neurologic disorders

JA Griffiths, SK Mazmanian - Genome medicine, 2018 - Springer
Editorial summary The gut microbiome contributes to the development and function of the
immune, metabolic, and nervous systems. Furthermore, commensal bacteria modulate …

[HTML][HTML] Treatment effect of bumetanide in children with autism spectrum disorder: a systematic review and meta-analysis

T Wang, L Shan, C Miao, Z Xu, F Jia - Frontiers in Psychiatry, 2021 - frontiersin.org
Background: The therapeutic effect of bumetanide on autism spectrum disorder (ASD)
seems to be controversial. To obtain better evidence on the efficacy of bumetanide, a …

The effect of lead exposure on autism development

A Goel, M Aschner - International Journal of Molecular Sciences, 2021 - mdpi.com
Autism Spectrum Disorder (ASD) remains one of the most detrimental neurodevelopmental
conditions in society today. Common symptoms include diminished social and …

Resolving the synaptic versus developmental dichotomy of autism risk genes

WE Heavner, SEP Smith - Trends in neurosciences, 2020 - cell.com
Genes that are mutated in Autism Spectrum Disorders (ASD) can be classified broadly as
either synaptic or developmental. But what if this is a false distinction? A recent spate of …

Disruption of circadian rhythm and risk of autism spectrum disorder: role of immune-inflammatory, oxidative stress, metabolic and neurotransmitter pathways

F Abdul, N Sreenivas, JVS Kommu… - Reviews in the …, 2022 - degruyter.com
Circadian rhythms in most living organisms are regulated by light and synchronized to an
endogenous biological clock. The circadian clock machinery is also critically involved in …