Hippocampal sclerosis in epilepsy: a neuropathology review

M Thom - Neuropathology and applied neurobiology, 2014 - Wiley Online Library
Hippocampal sclerosis (HS) is a common pathology encountered in mesial temporal lobe
epilepsy (MTLE) as well as other epilepsy syndromes and in both surgical and post‐mortem …

An update for epilepsy research and antiepileptic drug development: Toward precise circuit therapy

Y Wang, Z Chen - Pharmacology & therapeutics, 2019 - Elsevier
Epilepsy involves neuronal dysfunction at molecular, cellular, and circuit levels. The
understanding of the mechanism of the epilepsies has advanced greatly in the last three …

Epilepsy: new advances

SL Moshé, E Perucca, P Ryvlin, T Tomson - The Lancet, 2015 - thelancet.com
Epilepsy affects 65 million people worldwide and entails a major burden in seizure-related
disability, mortality, comorbidities, stigma, and costs. In the past decade, important advances …

A sensitive and specific nanosensor for monitoring extracellular potassium levels in the brain

J Liu, F Li, Y Wang, L Pan, P Lin, B Zhang… - Nature …, 2020 - nature.com
Extracellular potassium concentration affects the membrane potential of neurons, and, thus,
neuronal activity. Indeed, alterations of potassium levels can be related to neurological …

Forecasting stroke-like episodes and outcomes in mitochondrial disease

YS Ng, NZ Lax, AP Blain, D Erskine, MR Baker… - Brain, 2022 - academic.oup.com
In this retrospective, multicentre, observational cohort study, we sought to determine the
clinical, radiological, EEG, genetics and neuropathological characteristics of mitochondrial …

[PDF][PDF] Expression of the neuronal tRNA n-Tr20 regulates synaptic transmission and seizure susceptibility

M Kapur, A Ganguly, G Nagy, SI Adamson, JH Chuang… - Neuron, 2020 - cell.com
The mammalian genome has hundreds of nuclear-encoded tRNAs, but the contribution of
individual tRNA genes to cellular and organismal function remains unknown. Here, we …

[HTML][HTML] Increased segregation of brain networks in focal epilepsy: an fMRI graph theory finding

M Pedersen, AH Omidvarnia, JM Walz, GD Jackson - NeuroImage: Clinical, 2015 - Elsevier
Focal epilepsy is conceived of as activating local areas of the brain as well as engaging
regional brain networks. Graph theory represents a powerful quantitative framework for …

Role of the Fyn-PKCδ signaling in SE-induced neuroinflammation and epileptogenesis in experimental models of temporal lobe epilepsy

S Sharma, S Carlson, S Puttachary, S Sarkar… - Neurobiology of …, 2018 - Elsevier
Status epilepticus (SE) induces neuroinflammation and epileptogenesis, but the
mechanisms are not yet fully delineated. The Fyn, a non-receptor Src family tyrosine kinase …

Chimera states in hybrid coupled neuron populations

A Calim, JJ Torres, M Ozer, M Uzuntarla - Neural Networks, 2020 - Elsevier
Here we study the emergence of chimera states, a recently reported phenomenon referring
to the coexistence of synchronized and unsynchronized dynamical units, in a population of …

[HTML][HTML] Vagus nerve stimulation elicits sleep EEG desynchronization and network changes in responder patients in epilepsy

S Vespa, J Heyse, L Stumpp, G Liberati, SF Santos… - …, 2021 - Elsevier
Neural desynchronization was shown as a key mechanism of vagus nerve stimulation (VNS)
action in epilepsy, and EEG synchronization measures are explored as possible response …